日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide transcription factor-binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

全基因组转录因子结合图谱揭示了人类造血干细胞调控结构的细胞特异性变化

Subramanian, Shruthi; Thoms, Julie A I; Huang, Yizhou; Cornejo-Páramo, Paola; Koch, Forrest C; Jacquelin, Sebastien; Shen, Sylvie; Song, Emma; Joshi, Swapna; Brownlee, Chris; Woll, Petter S; Chacon-Fajardo, Diego; Beck, Dominik; Curtis, David J; Yehson, Kenneth; Antonenas, Vicki; O'Brien, Tracey; Trickett, Annette; Powell, Jason A; Lewis, Ian D; Pitson, Stuart M; Gandhi, Maher K; Lane, Steven W; Vafaee, Fatemeh; Wong, Emily S; Göttgens, Berthold; Alinejad-Rokny, Hamid; Wong, Jason W H; Pimanda, John E

Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41

RUNX1、GATA2 和 DDX41 基因种系变异引起的遗传性造血系统恶性肿瘤的体细胞突变图谱

Homan, Claire C; Drazer, Michael W; Yu, Kai; Lawrence, David M; Feng, Jinghua; Arriola-Martinez, Luis; Pozsgai, Matthew J; McNeely, Kelsey E; Ha, Thuong; Venugopal, Parvathy; Arts, Peer; King-Smith, Sarah L; Cheah, Jesse; Armstrong, Mark; Wang, Paul; Bödör, Csaba; Cantor, Alan B; Cazzola, Mario; Degelman, Erin; DiNardo, Courtney D; Duployez, Nicolas; Favier, Remi; Fröhling, Stefan; Rio-Machin, Ana; Klco, Jeffery M; Krämer, Alwin; Kurokawa, Mineo; Lee, Joanne; Malcovati, Luca; Morgan, Neil V; Natsoulis, Georges; Owen, Carolyn; Patel, Keyur P; Preudhomme, Claude; Raslova, Hana; Rienhoff, Hugh; Ripperger, Tim; Schulte, Rachael; Tawana, Kiran; Velloso, Elvira; Yan, Benedict; Kim, Erika; Sood, Raman; Hsu, Amy P; Holland, Steven M; Phillips, Kerry; Poplawski, Nicola K; Babic, Milena; Wei, Andrew H; Forsyth, Cecily; Mar Fan, Helen; Lewis, Ian D; Cooney, Julian; Susman, Rachel; Fox, Lucy C; Blombery, Piers; Singhal, Deepak; Hiwase, Devendra; Phipson, Belinda; Schreiber, Andreas W; Hahn, Christopher N; Scott, Hamish S; Liu, Paul; Godley, Lucy A; Brown, Anna L

Author Correction: Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia

作者更正:线粒体复合物 I 的种系突变揭示了 IDH1 突变型急性髓系白血病的遗传和可靶向脆弱性

Bassal, Mahmoud A; Samaraweera, Saumya E; Lim, Kelly; Benard, Brooks A; Bailey, Sheree; Kaur, Satinder; Leo, Paul; Toubia, John; Thompson-Peach, Chloe; Nguyen, Tran; Maung, Kyaw Ze Ya; Casolari, Debora A; Iarossi, Diana G; Pagani, Ilaria S; Powell, Jason; Pitson, Stuart; Natera, Siria; Roessner, Ute; Lewis, Ian D; Brown, Anna L; Tenen, Daniel G; Robinson, Nirmal; Ross, David M; Majeti, Ravindra; Gonda, Thomas J; Thomas, Daniel; D'Andrea, Richard J

RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML

RUNX1突变家族表现出表型异质性,并具有生殖系易感急性髓系白血病特有的体细胞突变谱。

Brown, Anna L; Arts, Peer; Carmichael, Catherine L; Babic, Milena; Dobbins, Julia; Chong, Chan-Eng; Schreiber, Andreas W; Feng, Jinghua; Phillips, Kerry; Wang, Paul P S; Ha, Thuong; Homan, Claire C; King-Smith, Sarah L; Rawlings, Lesley; Vakulin, Cassandra; Dubowsky, Andrew; Burdett, Jessica; Moore, Sarah; McKavanagh, Grace; Henry, Denae; Wells, Amanda; Mercorella, Belinda; Nicola, Mario; Suttle, Jeffrey; Wilkins, Ella; Li, Xiao-Chun; Michaud, Joelle; Brautigan, Peter; Cannon, Ping; Altree, Meryl; Jaensch, Louise; Fine, Miriam; Butcher, Carolyn; D'Andrea, Richard J; Lewis, Ian D; Hiwase, Devendra K; Papaemmanuil, Elli; Horwitz, Marshall S; Natsoulis, Georges; Rienhoff, Hugh Y; Patton, Nigel; Mapp, Sally; Susman, Rachel; Morgan, Susan; Cooney, Julian; Currie, Mark; Popat, Uday; Bochtler, Tilmann; Izraeli, Shai; Bradstock, Kenneth; Godley, Lucy A; Krämer, Alwin; Fröhling, Stefan; Wei, Andrew H; Forsyth, Cecily; Mar Fan, Helen; Poplawski, Nicola K; Hahn, Christopher N; Scott, Hamish S

Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia

CDK9/BET联合抑制在MLL重排急性白血病临床前模型中的疗效

McCalmont, Hannah; Li, Ka Leung; Jones, Luke; Toubia, John; Bray, Sarah C; Casolari, Debora A; Mayoh, Chelsea; Samaraweera, Saumya E; Lewis, Ian D; Prinjha, Rab K; Smithers, Nicholas; Wang, Shudong; Lock, Richard B; D'Andrea, Richard J

Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation

一项前瞻性、随机、双盲、III期临床试验,旨在评估抗T淋巴细胞球蛋白对接受HLA匹配无关供者清髓性造血干细胞移植患者慢性移植物抗宿主病无进展生存期的影响。

Soiffer, Robert J; Kim, Haesook T; McGuirk, Joseph; Horwitz, Mitchell E; Johnston, Laura; Patnaik, Mrinal M; Rybka, Witold; Artz, Andrew; Porter, David L; Shea, Thomas C; Boyer, Michael W; Maziarz, Richard T; Shaughnessy, Paul J; Gergis, Usama; Safah, Hana; Reshef, Ran; DiPersio, John F; Stiff, Patrick J; Vusirikala, Madhuri; Szer, Jeff; Holter, Jennifer; Levine, James D; Martin, Paul J; Pidala, Joseph A; Lewis, Ian D; Ho, Vincent T; Alyea, Edwin P; Ritz, Jerome; Glavin, Frank; Westervelt, Peter; Jagasia, Madan H; Chen, Yi-Bin

A Phase 2/3 Multicenter, Randomized, Open-Label Study to Compare the Efficacy and Safety of Lenalidomide Versus Investigator's Choice in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma

一项 II/III 期多中心、随机、开放标签研究,旨在比较来那度胺与研究者选择的药物在复发或难治性弥漫性大 B 细胞淋巴瘤患者中的疗效和安全性。

Czuczman, Myron S; Trněný, Marek; Davies, Andrew; Rule, Simon; Linton, Kim M; Wagner-Johnston, Nina; Gascoyne, Randy D; Slack, Graham W; Brousset, Pierre; Eberhard, David A; Hernandez-Ilizaliturri, Francisco J; Salles, Gilles; Witzig, Thomas E; Zinzani, Pier Luigi; Wright, George W; Staudt, Louis M; Yang, Yandan; Williams, P Mickey; Lih, Chih-Jian; Russo, Jacqueline; Thakurta, Anjan; Hagner, Patrick; Fustier, Pierre; Song, Dale; Lewis, Ian D

Early treatment intensification with R-ICE and 90Y-ibritumomab tiuxetan (Zevalin)-BEAM stem cell transplantation in patients with high-risk diffuse large B-cell lymphoma patients and positive interim PET after 4 cycles of R-CHOP-14

对于接受 4 个疗程 R-CHOP-14 治疗后中期 PET 检查结果呈阳性的高危弥漫性大 B 细胞淋巴瘤患者,早期强化治疗方案为 R-ICE 联合 90Y-伊布妥单抗(Zevalin)-BEAM 干细胞移植。

Hertzberg, Mark; Gandhi, Maher K; Trotman, Judith; Butcher, Belinda; Taper, John; Johnston, Amanda; Gill, Devinder; Ho, Shir-Jing; Cull, Gavin; Fay, Keith; Chong, Geoff; Grigg, Andrew; Lewis, Ian D; Milliken, Sam; Renwick, William; Hahn, Uwe; Filshie, Robin; Kannourakis, George; Watson, Anne-Marie; Warburton, Pauline; Wirth, Andrew; Seymour, John F; Hofman, Michael S; Hicks, Rodney J

Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome

红细胞同种免疫与骨髓增生异常综合征中自身抗体的产生和红细胞输注需求的增加有关。

Singhal, Deepak; Kutyna, Monika M; Chhetri, Rakchha; Wee, Li Yan A; Hague, Sophia; Nath, Lakshmi; Nath, Shriram V; Sinha, Romi; Wickham, Nicholas; Lewis, Ian D; Ross, David M; Bardy, Peter G; To, Luen Bik; Reynolds, John; Wood, Erica M; Roxby, David J; Hiwase, Devendra K

VEGF-A is increased in exogenous endophthalmitis

外源性眼内炎中 VEGF-A 增多

Mark E Seamone, Darrell R Lewis, Ian D Haidl, R Rishi Gupta, Daniel M O' Brien, John Dickinson, Arif Samad, Jean S Marshall, Alan F Cruess