日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Env抗体共同进化表明B细胞启动是HIV V2顶端广泛中和抗体发展的主要瓶颈。

Habib Rumi, Roark Ryan S, Li Hui, Connell Andrew Jesse, Hogarty Michael P, Wagh Kshitij, Wang Shuyi, Marchitto Lorie, Skelly Ashwin N, Carey John W, Sowers Kirsten J, Ayyanathan Kasirajan, Plante Samantha J, Bibollet-Ruche Frederic, Park Younghoon, Agostino Colby J, Singh Ajay, Martella Christian L, Lewis Emily, Rando Juliette M, Chohan Neha, Lora Jinery, Ding Wenge, Campion Mary S, Zhao Chengyan, Liu Weimin, Li Yingying, Li Xuduo, Liang Bo, Chowdhury Rohan Roy, Amereh Khaled, Van Itallie Elizabeth, Sheng Zizhang, Ghosh Amrit R, Bar Katharine J, Williams Wilton B, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Cain Derek W, Lewis Mark G, Batista Facundo D, Burton Dennis R, Andrabi Raiees, Kulp Daniel W, Haynes Barton F, Korber Bette, Shapiro Lawrence, Kwong Peter D, Hahn Beatrice H, Shaw George M

Durable protection against SIV challenge by adeno-associated virus delivery of Env-specific antibodies

通过腺相关病毒递送Env特异性抗体,实现对SIV攻击的持久保护

Barnacle, James R; Bangani, Nonzwakazi; Slawinski, Hubert; Barrington, Christopher; Wilkinson, Katalin A; Stek, Cari J; Lai, Rachel; Bonnet, Fabrice; Meintjes, Graeme; Robertson, Brian; Gengenbacher, Martin; Davis, Angharad G; Barber, Daniel L; O'Garra, Anne; Wilkinson, Robert J; Clark, Natasha M; Keles, Nida K; Hagedorn, Grace N; Klenchin, Vadim A; Andersen, Hanne; Treece, Jim; Fennessey, Christine M; Xie, Jun; Denny, Thomas N; DeMarco, C Todd; Hernandez, Jose S; Capuano, Saverio; Gardner, Matthew R; Keele, Brandon F; Gao, Guangping; Lewis, Mark G; Roederer, Mario; Evans, David T

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.

早期克隆优势决定了 HIV 血清中和的广泛进程。

Liang Bo, Zhu Yuxin, Roark Ryan S, Li Xuduo, Mishra Nitesh, Martella Christian L, Vo Anh L, Giese Gabriella, Huang Qin, Biju Andrea, Tjio Lifei, Chowdhury Rohan Roy, Oberoi Prabhgun, Amereh Khaled, Wani Areeba A, Zhang Yuexiu, Andrabi Sharaf, Sekar Tharunika V, Somanathan Anjali, Kassab Muzaffer, Nedellec Rebecca, Callaghan Sean, Avillion Gabriel, Lewis Mark G, Sackett Sara Dutton, Skelly Ashwin N, Bibollet-Ruche Frederic, Shapiro Lawrence, Sheng Zizhang, Briney Bryan, Hahn Beatrice H, Burton Dennis R, Irvine Darrell J, Kwong Peter D, Shaw George M, Andrabi Raiees

Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.

非稳定型 SARS-CoV-2 刺突 mRNA 疫苗可在非人灵长类动物中诱导产生广谱中和抗体。

Malewana R Dilshan, Stalls Victoria, May Aaron, Lu Xiaozhi, Martinez David R, Schäfer Alexandra, Li Dapeng, Barr Maggie, Sutherland Laura L, Lee Esther, Parks Robert, Beck Whitney Edwards, Newman Amanda, Bock Kevin W, Minai Mahnaz, Nagata Bianca M, DeMarco C Todd, Denny Thomas N, Oguin Thomas H 3rd, Rountree Wes, Wang Yunfei, Mansouri Katayoun, Edwards Robert J, Smith Lena, Sempowski Gregory D, Eaton Amanda, Muramatsu Hiromi, Henderson Rory, Tam Ying, Barbosa Christopher, Tang Juanjie, Cain Derek W, Santra Sampa, Moore Ian N, Andersen Hanne, Lewis Mark G, Golding Hana, Seder Robert, Khurana Surender, Montefiori David C, Pardi Norbert, Weissman Drew, Baric Ralph S, Acharya Priyamvada, Haynes Barton F, Saunders Kevin O

B-cell Follicles in the Secondary Lymphatic Tissues Act as a Critical Microanatomical Niche for Sustained Viral Replication, Virus-host Interaction and Damage During Chronic SIV Infection of Rhesus Macaques

在恒河猴慢性SIV感染期间,次级淋巴组织中的B细胞滤泡是病毒持续复制、病毒-宿主相互作用和损伤的关键微解剖学微环境。

Cheng, Yilun; Zhao, Miaoyun; Chen, Jackson; Mandal, Subhra; Lewis, Mark G; Li, Qingsheng

Analysis of SIV Spatiotemporal Dissemination Patterns in Rhesus Macaques During Early Rectal Transmission Demonstrates Systemic Infection Does Not Require Viral Local Amplification at the Entry Portal

对恒河猴早期直肠传播过程中SIV时空传播模式的分析表明,全身感染并不需要病毒在入口处的局部扩增。

Cheng, Yilun; Chen, Jackson; Zhao, Miaoyun; Mandal, Subhra; Lewis, Mark G; Luo, Ma; Gale, Michael; Li, Qingsheng

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

通过一种新型两步机制持续诱导广谱中和HIV抗体,为免疫原设计提供指导

Skelly, Ashwin N; Gristick, Harry B; Li, Hui; Gavor, Edem; Connell, Andrew J; Kreider, Edward F; Marchitto, Lorie; Hogarty, Michael P; Newby, Maddy L; Allen, Joel D; Liu, Weimin; West, Anthony P Jr; Ayyanathan, Kasirajan; Campion, Mary S; Winters, Kaitlyn; Gordon, Colette G; Osbaldeston, Rebecca A; Akeley, Macy J; Li, Yingying; Singh, Ajay; Cruickshank, Kendra; Park, Younghoon; Zhao, Chengyan; Li, Xuduo; Amereh, Khaled; Itallie, Elizabeth Van; Carey, John W; Albertus, Amie; DeLaitsch, Andrew T; Keeffe, Jennifer R; Lituchy, Melinda G; Walsh, Agnes A; Morris, Daniel J; Habib, Rumi; Bibollet-Ruche, Frederic; Mishra, Nitesh; Avillion, Gabriel; Koranda, Nicholas S; Plante, Samantha J; Martella, Christian L; Lora, Jinery; Wang, Eric J D; Lewis, Mark G; Martin, Malcolm A; Nussenzweig, Michel C; Seaman, Michael S; Irvine, Darrell J; Wiehe, Kevin J; Haynes, Barton F; Wagh, Kshitij; Korber, Bette T; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Bjorkman, Pamela J; Hahn, Beatrice H; Shaw, George M

Correction: Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates

更正:CRISPR靶向SIV在非人灵长类动物中的临床前安全性和生物分布

Burdo, Tricia H; Chen, Chen; Kaminski, Rafal; Sariyer, Ilker K; Mancuso, Pietro; Donadoni, Martina; Smith, Mandy D; Sariyer, Rahsan; Caocci, Maurizio; Liao, Shuren; Liu, Hong; Huo, Wenwen; Zhao, Huaqing; Misamore, John; Lewis, Mark G; Simonyan, Vahan; Thompson, Elaine E; Xu, Ethan Y; Cradick, Thomas J; Gordon, Jennifer; Khalili, Kamel

Protective threshold of a potent neutralizing Zika virus monoclonal antibody in rhesus macaques

强效中和寨卡病毒单克隆抗体在恒河猴中的保护阈值

Nkolola, Joseph P; Hope, David; Guan, Ruoran; Colarusso, Alessandro; Aid, Malika; Weiss, Deborah; Misamore, John; Andersen, Hanne; Lewis, Mark G; Williamson, Lauren; Carnahan, Robert H; Crowe, James E Jr; Barouch, Dan H

SARS-CoV-2 mucosal vaccine protects against clinical disease with sex bias in efficacy.

SARS-CoV-2 黏膜疫苗可预防临床疾病,但其疗效存在性别差异

Sui Yongjun, Andersen Hanne, Li Jianping, Hoang Tanya, Minai Mahnaz, Nagata Bianca M, Bock Kevin W, Alves Derron A, Lewis Mark G, Berzofsky Jay A