日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease

一项针对轻度认知障碍和阿尔茨海默病引起的轻度至中度痴呆的tau蛋白聚集抑制剂甲磺酸氢甲基硫氨酸的3期临床试验的临床、影像学和血液生物标志物结果

Wischik, Claude M; Stefanacci, Richard; Bentham, Peter; Gauthier, Serge; Zetterberg, Henrik; Wilcock, Gordon K; Froelich, Lutz; Burns, Alistair; MacSweeney, Emer; Ballard, Clive; Yu, Jin-Tai; Choon, Tay Siew; Asvatourian, Vahe; Muehlemann, Natalia; Priel, Jan; Kook, Karin; Sullivan, Tenecia; Downie, Diane; Miller, Sonya; Pringle, Carol; Storey, John M D; Baddeley, Tom; Harrington, Charles R; Penny, Lewis K; Arastoo, Mohammad; Staff, Roger; Sandu, Anca-Larisa; Shiells, Helen; Lo, Serena; Nazlee, Nafeesa; Evans, Emily; Hull, Claire; Schelter, Bjoern O

Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model

时机至关重要:在小鼠tau蛋白病模型中,早期注射靶向tau重复结构域的高亲和力抗体可预防聚集。

Penny, Lewis K; Arastoo, Mohammad; Lofthouse, Richard; Abdallah, Aya; Imoesi, Peter I; Schwab, Karima; Shiells, Helen; Melis, Valeria; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Porter, Andrew; Palliyil, Soumya

Redox-driven mineral and organic associations in Jezero Crater, Mars

火星耶泽罗陨石坑中氧化还原驱动的矿物和有机物结合

Hurowitz, Joel A; Tice, M M; Allwood, A C; Cable, M L; Hand, K P; Murphy, A E; Uckert, K; Bell, J F 3rd; Bosak, T; Broz, A P; Clavé, E; Cousin, A; Davidoff, S; Dehouck, E; Farley, K A; Gupta, S; Hamran, S-E; Hickman-Lewis, K; Johnson, J R; Jones, A J; Jones, M W M; Jørgensen, P S; Kah, L C; Kalucha, H; Kizovski, T V; Klevang, D A; Liu, Y; McCubbin, F M; Moreland, E L; Paar, G; Paige, D A; Pascuzzo, A C; Rice, M S; Schmidt, M E; Siebach, K L; Siljeström, S; Simon, J I; Stack, K M; Steele, A; Tosca, N J; Treiman, A H; VanBommel, S J; Wade, L A; Weiss, B P; Wiens, R C; Williford, K H; Barnes, R; Barr, P A; Bechtold, A; Beck, P; Benzerara, K; Bernard, S; Beyssac, O; Bhartia, R; Brown, A J; Caravaca, G; Cardarelli, E L; Cloutis, E A; Fairén, A G; Flannery, D T; Fornaro, T; Fouchet, T; Garczynski, B; Goméz, F; Hausrath, E M; Heirwegh, C M; Herd, C D K; Huggett, J E; Jørgensen, J L; Lee, S W; Li, A Y; Maki, J N; Mandon, L; Mangold, N; Manrique, J A; Martínez-Frías, J; Núñez, J I; O'Neil, L P; Orenstein, B J; Phelan, N; Quantin-Nataf, C; Russell, P; Schulte, M D; Scheller, E; Sharma, S; Shuster, D L; Srivastava, A; Wogsland, B V; Wolf, Z U

Transcriptome mining reveals diversity and evolution of circulating and endogenous amphibian retroviruses

转录组挖掘揭示了循环和内源性两栖动物逆转录病毒的多样性和进化

Harding, Emma F; Webster, Banjo; Sridhar, Tanu; Mercer, Lewis K; White, Peter A

Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer's disease.

血浆中含有富含脯氨酸区域的 tau 蛋白种类的定量分析,作为阿尔茨海默病的生物标志物。

Arastoo Mohammad, Penny Lewis K, Lofthouse Richard, Hitchcock Aaron, Moelders Anna, Szalma Sona, Porter Andrew, Palliyil Soumya, Harrington Charles R, Wischik Claude M

Atlasprofilax: a new promising treatment for chronic cervicobrachialgia. A qualitative-quantitative research of a retrospective longitudinal section, with a cause-effect approach

Atlasprofilax:一种治疗慢性颈臂痛的新型有效疗法。一项采用因果关系方法的回顾性纵向研究,结合定性和定量分析。

Rezende, R; León Higuera, J G; Manent, L; Lewis, K; Angulo, O

Malaria prevalence, transmission potential and efficacy of artemisinin-based combination therapy in the Kenyan Central highlands: a zone previously characterized as malaria-free

肯尼亚中部高地疟疾流行情况、传播潜力及青蒿素联合疗法疗效:该地区此前被认为是无疟疾地区。

Kimani, Francis T; Thiongó, Kelvin K; Otinga, Maureen A; Mbabu, Lewis K; Ombati, Mary N; Kitur, Stanley K; Ochieng', Sarah A; Wachira, Lucy N; Matoke-Muhia, Damaris K; Kamau, Luna

Metabolomic Signatures in Adults with Metabolic Syndrome Indicate Preclinical Disruptions in Pathways Associated with High-Density Lipoprotein Cholesterol, Sugar Alcohols

代谢综合征成人患者的代谢组学特征表明,与高密度脂蛋白胆固醇、糖醇相关的通路存在临床前紊乱

Lewis, K A; Stroebel, Benjamin M; Kanaya, Alka M; Aouizerat, Bradley; Longoria, Kayla D; Flowers, Elena

Metabolomic signatures in adults with metabolic syndrome indicate preclinical disruptions in pathways associated with high-density lipoprotein cholesterol, sugar alcohols

代谢综合征成人患者的代谢组学特征表明,与高密度脂蛋白胆固醇、糖醇相关的通路存在临床前紊乱。

Lewis, K A; Stroebel, Benjamin M; Kanaya, Alka M; Aouizerat, Bradley; Longoria, Kayla D; Flowers, Elena

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease

针对阿尔茨海默病tau蛋白靶向疗法的临床试验中生物标志物策略的考量

Penny, Lewis K; Lofthouse, Richard; Arastoo, Mohammad; Porter, Andy; Palliyil, Soumya; Harrington, Charles R; Wischik, Claude M