日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

具有 Gα 结合和激活基序的非 GPCR 蛋白激活 Gαi 的分子机制

期刊:Nature Communications
影响因子:15.7
doi:10.1038/ncomms15163
de Opakua Alain Ibáñez, Parag-Sharma Kshitij, DiGiacomo Vincent, Merino Nekane, Leyme Anthony, Marivin Arthur, Villate Maider, Nguyen Lien T, de la Cruz-Morcillo Miguel Angel, Blanco-Canosa Juan B, Ramachandran Sekar, Baillie George S, Cerione Richard A, Blanco Francisco J, Garcia-Marcos Mikel
免疫/内分泌
发表日期：2017
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Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein

通过合理设计的蛋白质特异性抑制GPCR非依赖性G蛋白信号传导

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1707992114
Leyme, Anthony; Marivin, Arthur; Maziarz, Marcin; DiGiacomo, Vincent; Papakonstantinou, Maria P; Patel, Prachi P; Blanco-Canosa, Juan B; Walawalkar, Isha A; Rodriguez-Davila, Gonzalo; Dominguez, Isabel; Garcia-Marcos, Mikel
信号转导
GPCR/Calcium/cAMP
发表日期：2017
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GIV/Girdin activates Gαi and inhibits Gαs via the same motif

GIV/Girdin 通过同一基序激活 Gαi 并抑制 Gαs。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1609502113
Gupta, Vijay; Bhandari, Deepali; Leyme, Anthony; Aznar, Nicolas; Midde, Krishna K; Lo, I-Chung; Ear, Jason; Niesman, Ingrid; López-Sánchez, Inmaculada; Blanco-Canosa, Juan Bautista; von Zastrow, Mark; Garcia-Marcos, Mikel; Farquhar, Marilyn G; Ghosh, Pradipta
Girdin
发表日期：2016
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Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease.

显性负性 Gα 亚基是人类疾病中异源三聚体 G 蛋白信号传导失调的一种机制

期刊:Science Signaling
影响因子:6.6
doi:10.1126/scisignal.aad2429
Marivin Arthur, Leyme Anthony, Parag-Sharma Kshitij, DiGiacomo Vincent, Cheung Anthony Y, Nguyen Lien T, Dominguez Isabel, Garcia-Marcos Mikel
免疫/内分泌
Human
发表日期：2016
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Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy

细胞周期蛋白依赖性激酶5激活鸟嘌呤核苷酸交换因子GIV/Girdin，从而调控细胞迁移与增殖的二分性。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1514157112
Bhandari, Deepali; Lopez-Sanchez, Inmaculada; To, Andrew; Lo, I-Chung; Aznar, Nicolas; Leyme, Anthony; Gupta, Vijay; Niesman, Ingrid; Maddox, Adam L; Garcia-Marcos, Mikel; Farquhar, Marilyn G; Ghosh, Pradipta
信号转导
细胞生物学
Girdin
发表日期：2015
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