日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure and Mechanism of PhdC, a Prenylated-Flavin Maturase

PhdC(一种异戊二烯化黄素成熟酶)的结构和机制

Whittall, Dominic R; Box, Henry G; Payne, Karl A P; Marshall, Stephen A; Leys, David

Engineered enzymes for enantioselective nucleophilic aromatic substitutions

用于对映选择性亲核芳香取代反应的工程酶

Lister, Thomas M; Roberts, George W; Hossack, Euan J; Zhao, Fei; Burke, Ashleigh J; Johannissen, Linus O; Hardy, Florence J; Millman, Alexander A V; Leys, David; Larrosa, Igor; Green, Anthony P

Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.

基于片段的小分子抑制剂开发靶向结核分枝杆菌胆固醇代谢

Kavanagh Madeline E, McLean Kirsty J, Gilbert Sophie H, Amadi Cecilia N, Snee Matthew, Tunnicliffe Richard B, Arora Kriti, Boshoff Helena I M, Fanourakis Alexander, Rebollo-Lopez Maria Jose, Ortega Fatima, Levy Colin W, Munro Andrew W, Leys David, Abell Chris, Coyne Anthony G

Photocobilins integrate B(12) and bilin photochemistry for enzyme control

光胆素整合维生素B12和胆素的光化学反应,从而控制酶活性。

Zhang, Shaowei; Jeffreys, Laura N; Poddar, Harshwardhan; Yu, Yuqi; Liu, Chuanyang; Patel, Kaylee; Johannissen, Linus O; Zhu, Lingyun; Cliff, Matthew J; Yan, Cunyu; Schirò, Giorgio; Weik, Martin; Sakuma, Michiyo; Levy, Colin W; Leys, David; Heyes, Derren J; Scrutton, Nigel S

The prFMNH(2)-binding chaperone LpdD assists UbiD decarboxylase activation

prFMNH(2)结合分子伴侣LpdD辅助UbiD脱羧酶活化。

Gahloth, Deepankar; Fisher, Karl; Marshall, Stephen; Leys, David

Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism

基于片段的小分子抑制剂开发靶向结核分枝杆菌胆固醇代谢

Kavanagh, Madeline E; McLean, Kirsty J; Gilbert, Sophie H; Amadi, Cecilia; Snee, Matthew; Tunnicliffe, Richard B; Arora, Kriti; Boshoff, Helena I; Fanourakis, Alexander; Rebello-Lopez, Maria Jose; Ortega-Muro, Fatima; Levy, Colin W; Munro, Andrew W; Leys, David; Abell, Chris; Coyne, Anthony G

Efficient NADPH-dependent dehalogenation afforded by a self-sufficient reductive dehalogenase

高效的NADPH依赖性脱卤反应由一种自给自足的还原脱卤酶提供

Fisher, Karl; Halliwell, Tom; Payne, Karl A P; Ragala, Gabriel; Hay, Sam; Rigby, Stephen E J; Leys, David

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

基于结构的结核分枝杆菌CYP125和CYP142抑制剂的发现

Katariya, Mona M; Snee, Matthew; Tunnicliffe, Richard B; Kavanagh, Madeline E; Boshoff, Helena I M; Amadi, Cecilia N; Levy, Colin W; Munro, Andrew W; Abell, Chris; Leys, David; Coyne, Anthony G; McLean, Kirsty J

A Vitamin B(2) -Photocatalysed Approach to Methionine Analogues

维生素B(2)光催化合成蛋氨酸类似物的方法

Knowles, Oliver J; Johannissen, Linus O; Crisenza, Giacomo E M; Hay, Sam; Leys, David; Procter, David J

Enzymatic N-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases

利用细菌还原氨酶催化可再生肉桂酸对伯胺和仲胺进行酶促N-烯丙基化反应

Aleku, Godwin A; Titchiner, Gabriel R; Roberts, George W; Derrington, Sasha R; Marshall, James R; Hollfelder, Florian; Turner, Nicholas J; Leys, David