日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A coronavirus assembly inhibitor that targets the viral membrane protein.

一种针对病毒膜蛋白的冠状病毒组装抑制剂

Laporte Manon, Jochmans Dirk, Bardiot Dorothée, Desmarets Lowiese, Debski-Antoniak Oliver J, Mizzon Giulia, Abdelnabi Rana, Leyssen Pieter, Chiu Winston, Zhang Zhikuan, Nomura Norimichi, Boland Sandro, Ohto Umeharu, Stahl Yannick, Wuyts Jurgen, De Jonghe Steven, Stevaert Annelies, van Hemert Martijn J, Bontes Brenda W, Wanningen Patrick, Groenewold G J Mirjam, Zegar Aneta, Owczarek Katarzyna, Joshi Sanjata, Koukni Mohamed, Arzel Philippe, Klaassen Hugo, Vanherck Jean-Christophe, Vandecaetsbeek Ilse, Cremers Niels, Donckers Kim, Francken Thibault, Van Buyten Tina, Rymenants Jasper, Schepers Joost, Pyrc Krzysztof, Hilgenfeld Rolf, Dubuisson Jean, Bosch Berend-Jan, Van Kuppeveld Frank, Eydoux Cecilia, Decroly Etienne, Canard Bruno, Naesens Lieve, Weynand Birgit, Snijder Eric J, Belouzard Sandrine, Shimizu Toshiyuki, Bartenschlager Ralf, Hurdiss Daniel L, Marchand Arnaud, Chaltin Patrick, Neyts Johan

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.

PIP4K2C 抑制可逆转 SARS-CoV-2 引起的自噬通量受损

Karim Marwah, Mishra Manjari, Lo Chieh-Wen, Saul Sirle, Cagirici Halise Busra, Gourdelier Manon, Ghita Luca, Ojha Amrita, Tran Do Hoang Nhu, Agrawal Aditi, McGraw Connor, East Michael P, Gammeltoft Karen Anbro, Sahoo Malaya Kumar, Mooney Nancie A, Johnson Gary L, Das Soumita, Leyssen Pieter, Neyts Johan, Chiu Winston, Cohen Courtney A, Bukh Jens, Gottwein Judith, Dye John M, Neff Norma, Jackson Peter K, Pinsky Benjamin A, Laitinen Tuomo, Pantsar Tatu, Poso Antti, Zanini Fabio, De Jonghe Steven, Asquith Christopher R M, Einav Shirit

6-Chlorocoumarin Conjugates with Nucleobases and Nucleosides as Potent Anti-Hepatitis C Virus Agents

6-氯香豆素与核碱基和核苷的缀合物作为强效抗丙型肝炎病毒药物

Lin, Shu-Yu; Huang, Wen-Chieh; Tsay, Shwu-Chen; Neyts, Johan; Leyssen, Pieter; Lin, Chun-Cheng; Hwang, Kuo Chu; Horng, Jia-Cherng; Hwu, Jih Ru

Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2

整合酶链转移抑制剂和衣壳抑制剂雷那卡帕韦对 HIV-2 的疗效以及雷替拉韦对 SARS-CoV-2 活性的影响探讨

Irene Wanjiru Kiarie, Gyula Hoffka, Manon Laporte, Pieter Leyssen, Johan Neyts, József Tőzsér, Mohamed Mahdi

Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

抗癌泛 ErbB 抑制剂可减轻炎症和组织损伤并发挥广谱抗病毒作用

Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A Boghdeh, Do Hn Tran, Courtney A Cohen, Jacquelyn A Brown, Kathleen E Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy

Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2

鉴定出一种具有广谱细胞特异性活性的 Cathepsin L 抑制剂 Z-Tyr-Ala-CHN2,可对抗冠状病毒(包括 SARS-CoV-2)

Jordi Doijen, Koen Temmerman, Christel Van den Eynde, Annick Diels, Nick Van den Broeck, Michiel Van Gool, Inha Heo, Steffen Jaensch, Marleen Zwaagstra, Mayra Diosa Toro, Winston Chiu, Steven De Jonghe, Pieter Leyssen, Denisa Bojkova, Sandra Ciesek, Jindrich Cinatl, Lore Verschueren, Christophe Buyc

Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial

在塞拉利昂儿童中,两剂异源Ad26.ZEBOV和MVA-BN-Filo埃博拉疫苗方案的安全性和免疫原性:一项随机、双盲、对照试验

Afolabi, Muhammed O; Ishola, David; Manno, Daniela; Keshinro, Babajide; Bockstal, Viki; Rogers, Baimba; Owusu-Kyei, Kwabena; Serry-Bangura, Alimamy; Swaray, Ibrahim; Lowe, Brett; Kowuor, Dickens; Baiden, Frank; Mooney, Thomas; Smout, Elizabeth; Köhn, Brian; Otieno, Godfrey T; Jusu, Morrison; Foster, Julie; Samai, Mohamed; Deen, Gibrilla Fadlu; Larson, Heidi; Lees, Shelley; Goldstein, Neil; Gallagher, Katherine E; Gaddah, Auguste; Heerwegh, Dirk; Callendret, Benoit; Luhn, Kerstin; Robinson, Cynthia; Greenwood, Brian; Leyssen, Maarten; Douoguih, Macaya; Leigh, Bailah; Watson-Jones, Deborah

Safety and long-term immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Sierra Leone: a combined open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2 trial

在塞拉利昂成人中,两剂异源Ad26.ZEBOV和MVA-BN-Filo埃博拉疫苗方案的安全性和长期免疫原性:一项开放标签、非随机I期试验和一项随机、双盲、对照II期试验的联合研究

Ishola, David; Manno, Daniela; Afolabi, Muhammed O; Keshinro, Babajide; Bockstal, Viki; Rogers, Baimba; Owusu-Kyei, Kwabena; Serry-Bangura, Alimamy; Swaray, Ibrahim; Lowe, Brett; Kowuor, Dickens; Baiden, Frank; Mooney, Thomas; Smout, Elizabeth; Köhn, Brian; Otieno, Godfrey T; Jusu, Morrison; Foster, Julie; Samai, Mohamed; Deen, Gibrilla Fadlu; Larson, Heidi; Lees, Shelley; Goldstein, Neil; Gallagher, Katherine E; Gaddah, Auguste; Heerwegh, Dirk; Callendret, Benoit; Luhn, Kerstin; Robinson, Cynthia; Leyssen, Maarten; Greenwood, Brian; Douoguih, Macaya; Leigh, Bailah; Watson-Jones, Deborah

Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

患者来源的单克隆抗体可中和SARS-CoV-2 Omicron变异株,并为猴子提供完全保护

Craig Fenwick # ,Priscilla Turelli # ,Dongchun Ni # ,Laurent Perez # ,Kelvin Lau ,Cécile Herate ,Romain Marlin ,Erica Lana ,Céline Pellaton ,Charlène Raclot ,Line Esteves-Leuenberger ,Jérémy Campos ,Alex Farina ,Flurin Fiscalini ,Nathalie Dereuddre-Bosquet ,Francis Relouzat ,Rana Abdelnabi ,Caroline S Foo ,Johan Neyts ,Pieter Leyssen ,Yves Lévy ,Florence Pojer ,Henning Stahlberg ,Roger LeGrand ,Didier Trono ,Giuseppe Pantaleo

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in children and adolescents in Africa: A randomised, placebo-controlled, multicentre Phase II clinical trial

在非洲儿童和青少年中,接种两剂异源Ad26.ZEBOV、MVA-BN-Filo埃博拉疫苗的安全性和免疫原性:一项随机、安慰剂对照、多中心II期临床试验

Anywaine, Zacchaeus; Barry, Houreratou; Anzala, Omu; Mutua, Gaudensia; Sirima, Sodiomon B; Eholie, Serge; Kibuuka, Hannah; Bétard, Christine; Richert, Laura; Lacabaratz, Christine; McElrath, M Juliana; De Rosa, Stephen C; Cohen, Kristen W; Shukarev, Georgi; Katwere, Michael; Robinson, Cynthia; Gaddah, Auguste; Heerwegh, Dirk; Bockstal, Viki; Luhn, Kerstin; Leyssen, Maarten; Thiébaut, Rodolphe; Douoguih, Macaya