Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies
TTF1 和 cMYC 蛋白的表达定义了小细胞肺癌的不同分子亚群,这些亚群对 Aurora 激酶抑制剂、DLL3 靶向治疗和其他靶向疗法具有独特的敏感性。
期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.20621
Cardnell, Robert J; Li, Lerong; Sen, Triparna; Bara, Rasha; Tong, Pan; Fujimoto, Junya; Ireland, Abbie S; Guthrie, Matthew R; Bheddah, Sheila; Banerjee, Upasana; Kalu, Nene N; Fan, You-Hong; Dylla, Scott J; Johnson, Faye M; Wistuba, Ignacio I; Oliver, Trudy G; Heymach, John V; Glisson, Bonnie S; Wang, Jing; Byers, Lauren A