日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

ENPP1缓冲棕色脂肪组织中的细胞外cGAMP,从而限制胰岛素抵抗。

Wang, Songnan; Guo, Yingjie; An, Weidong; Lee, Michelle; Li, Yu; Sudaryo, Valentino; Grenot, Gabriel; Skariah, Gemini; Reghupaty, Saranya C; Young, Sonny; Bai, Xiaochen; Svensson, Katrin J; Li, Lingyin

Cysteine allostery and autoinhibition govern human STING oligomer functionality.

半胱氨酸变构和自身抑制控制着人类 STING 寡聚体的功能。

Chan Rebecca, Cao Xujun, Ergun Sabrina L, Njomen Evert, Lynch Stephen R, Ritchie Christopher, Cravatt Benjamin, Li Lingyin

ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

ENPP1抑制剂具有超长的药物靶点停留时间,可作为一种先天免疫检查点阻断疗法用于癌症治疗。

Johnson, Randolph M; Wang, Songnan; Carozza, Jacqueline A; Fernandez, Daniel; Scicinski, Jan; Verity, Neil A; Mardjuki, Rachel; Cao, Xujun; Papkoff, Jacqueline; Ray, Nigel; Li, Lingyin

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

ENPP1 是抗癌 cGAMP-STING 通路的先天免疫检查点

Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

噬菌体抗CBASS蛋白可同时螯合环状三核苷酸和二核苷酸。

Cao, Xueli; Xiao, Yu; Huiting, Erin; Cao, Xujun; Li, Dong; Ren, Jie; Guan, Linlin; Wang, Yu; Li, Lingyin; Bondy-Denomy, Joseph; Feng, Yue

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.

激活 STING 依赖性 I 型干扰素反应可降低小胶质细胞反应性和神经炎症

Mathur Vidhu, Burai Ritwik, Vest Ryan T, Bonanno Liana N, Lehallier Benoit, Zardeneta Macy E, Mistry Karishma N, Do Danny, Marsh Samuel E, Abud Edsel M, Blurton-Jones Mathew, Li Lingyin, Lashuel Hilal A, Wyss-Coray Tony

Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

ENPP1 对 2'3'-cGAMP 的水解作用及不可水解类似物的设计

Li Lingyin, Yin Qian, Kuss Pia, Maliga Zoltan, Millán José L, Wu Hao, Mitchison Timothy J

Anticancer flavonoids are mouse-selective STING agonists

抗癌黄酮类化合物是小鼠选择性STING激动剂

Kim, Sujeong; Li, Lingyin; Maliga, Zoltan; Yin, Qian; Wu, Hao; Mitchison, Timothy J