Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.
巨噬细胞产生的乳酸通过 MCT1 启动的组蛋白 H3 赖氨酸 23 乳酸化，驱动皮肤真皮成纤维细胞表型重塑，形成肥厚性瘢痕。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69388-y
Yuan Yixuan, Xiao Yujie, Zou Jie, Luo Liang, Li Mengyang, Shen Kuo, Wei Lai, Zhang Yihao, Wang Peng, Chen Yan, Zhuo Shixuan, Zhang Hao, Song Shijie, Jia Yanhui, Wang Kejia, Jiang Shiqing, Guan Hao, Hu Dahai
巨噬细胞
成纤维细胞
巨噬细胞
乳酸化
细胞生物学
免疫/内分泌
