Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation
过量的核酸R环可诱导线粒体依赖性上皮细胞坏死,并引发自发性肠道炎症。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2307395120
Yang, Xu; Li, Guilin; Lou, Pengbo; Zhang, Mingxin; Yao, Kai; Xiao, Jintao; Chen, Yiqian; Xu, Jiuzhi; Tian, Shengyuan; Deng, Min; Pan, Yuwei; Li, Mengzhen; Wu, Xi; Liu, Ruiqi; Shi, Xiaojing; Tian, Yuhua; Yu, Lu; Ke, Hao; Jiao, Baowei; Cong, Yingzi; Plikus, Maksim V; Liu, Xiaowei; Yu, Zhengquan; Lv, Cong
炎症
肠炎
炎症/感染
上皮细胞
线粒体
细胞生物学
毒理研究