文献库，生知库 | 链接生命科学的每一步

Interactive Explainable Deep Learning Model for Hepatocellular Carcinoma Diagnosis at Gadoxetic Acid-enhanced MRI: A Retrospective, Multicenter, Diagnostic Study

基于钆塞酸增强磁共振成像的肝细胞癌诊断交互式可解释深度学习模型：一项回顾性、多中心诊断研究

Li, Mingkai; Zhang, Zhi; Chen, Zebin; Chen, Xi; Liu, Huaqing; Xiao, Yuanqiang; Chen, Haimei; Zong, Xiaodan; Chen, Jingbiao; Chen, Jianning; Wang, Xinying; Xiao, Xuehong; Yang, Zhiwei; Han, Lanqing; Wang, Jin; Wu, Bin

细胞生物学

The fibrosis investigating navigator in diabetes (FIND): A tool to predict liver fibrosis risk in subjects with diabetes

糖尿病肝纤维化研究导航工具（FIND）：一种预测糖尿病患者肝纤维化风险的工具

期刊:Diabetes Obesity & Metabolism

影响因子:5.7

doi:10.1111/dom.16109

Li, Mingkai; Yu, Hongsheng; Wan, Sizhe; Hu, Fulan; Luo, Qingtian; Gong, Wei

Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study

血清25(OH)D3和认知水平与老年人生物衰老的关系：一项横断面研究

期刊:Frontiers in Nutrition

影响因子:5.1

doi:10.3389/fnut.2025.1581610

Li, Mingkai; Li, Chenyang; Cheng, Le; Lv, Chenhui; Xue, Lushan; Zhang, Cheng; Bai, Ziping; Wang, Xi; Chen, Shuangzhi; Guo, Qinfei; Zhao, Yafei; Zhao, Haifeng

Introduction of human m(6)Am methyltransferase PCIF1 facilitates the biosynthesis of terpenoids in Saccharomyces cerevisiae

人源m(6)Am甲基转移酶PCIF1的引入促进了酿酒酵母中萜类化合物的生物合成

期刊:Microbial Cell Factories

影响因子:4.9

doi:10.1186/s12934-025-02701-4

Wang, Guoli; Li, Mingkai; Fan, Bengui; Liang, Xiqin; Wang, Jun; Shi, Yanbing; Zheng, Qiusheng; Li, Defang; An, Tianyue

发表日期：2025

文献求助收藏

Combined effects of sound and temperature on the composition and function of bacterial and fungal communities in loess

声音和温度对黄土中细菌和真菌群落组成和功能的综合影响

期刊:BMC Microbiology

影响因子:4.2

doi:10.1186/s12866-025-04540-0

Zhao, Liping; Li, Mingkai; Wang, YaLing; Chen, Li

微生物学

发表日期：2025

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Development and validation of a multimodal model integrating gut microbiota and metabolite for identifying sarcopenia in patients with MASLD: a study from two centers in China

开发和验证整合肠道菌群和代谢物的多模态模型，用于识别MASLD患者的肌少症：一项来自中国两家中心的研究

期刊:Nutrition Journal

影响因子:3.8

doi:10.1186/s12937-025-01198-2

Wan, Sizhe; Li, Mingkai; Li, Wanjun; Ren, Yuexiang; Wu, Yuankai; Luo, Qingtian; Gong, Wei

Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.

茶多酚通过激活SIRT1，增强M2巨噬细胞极化，改善老年DKD模型大鼠足细胞脂质积累和损伤

期刊:Food Science & Nutrition

影响因子:3.8

doi:10.1002/fsn3.70736

Chen Shuangzhi, Wang Xi, Li Chengyang, Cheng Le, Lv Chenhui, Xue Lushan, Zhang Cheng, Li Xuemin, Li Mingkai, Guo Qinfei, Zhao Yafei, Zhao Haifeng

Biosynthesis and metabolic engineering of natural sweeteners

天然甜味剂的生物合成和代谢工程

期刊:AMB Express

影响因子:3.7

doi:10.1186/s13568-025-01864-y

Fan, Bengui; Liang, Xiqin; Li, Yichi; Li, Mingkai; Yu, Tongle; Qin, Yuan; Li, Bohan; An, Tianyue; Wang, Guoli

代谢

发表日期：2025

文献求助收藏

Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE2 production

Spinster同源物2/S1P信号通路通过平衡PGE2的产生来减轻巨噬细胞对细菌感染的炎症反应。

期刊:Cell Communication and Signaling

影响因子:8.2

doi:10.1186/s12964-024-01851-z

Chao Fang # ,Pan Ren # ,Yejun He # ,Yitian Wang # ,Shuting Yao ,Congying Zhao ,Xueyong Li ,Xi Zhang ,Jinqing Li ,Mingkai Li

Pyrimidine nucleoside: inspiration for novel antimicrobial agent

嘧啶核苷：新型抗菌剂的灵感来源

Interactive Explainable Deep Learning Model for Hepatocellular Carcinoma Diagnosis at Gadoxetic Acid-enhanced MRI: A Retrospective, Multicenter, Diagnostic Study

基于钆塞酸增强磁共振成像的肝细胞癌诊断交互式可解释深度学习模型：一项回顾性、多中心诊断研究

The fibrosis investigating navigator in diabetes (FIND): A tool to predict liver fibrosis risk in subjects with diabetes

糖尿病肝纤维化研究导航工具（FIND）：一种预测糖尿病患者肝纤维化风险的工具

Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study

血清25(OH)D3和认知水平与老年人生物衰老的关系：一项横断面研究

Introduction of human m(6)Am methyltransferase PCIF1 facilitates the biosynthesis of terpenoids in Saccharomyces cerevisiae

人源m(6)Am甲基转移酶PCIF1的引入促进了酿酒酵母中萜类化合物的生物合成

Combined effects of sound and temperature on the composition and function of bacterial and fungal communities in loess

声音和温度对黄土中细菌和真菌群落组成和功能的综合影响

Development and validation of a multimodal model integrating gut microbiota and metabolite for identifying sarcopenia in patients with MASLD: a study from two centers in China

开发和验证整合肠道菌群和代谢物的多模态模型，用于识别MASLD患者的肌少症：一项来自中国两家中心的研究

Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.

茶多酚通过激活SIRT1，增强M2巨噬细胞极化，改善老年DKD模型大鼠足细胞脂质积累和损伤

Biosynthesis and metabolic engineering of natural sweeteners

天然甜味剂的生物合成和代谢工程

Spinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE2 production

Spinster同源物2/S1P信号通路通过平衡PGE2的产生来减轻巨噬细胞对细菌感染的炎症反应。