Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer
UHRF家族蛋白频繁过表达对DNMT3A从头DNA甲基化的负调控是癌症中广泛存在的DNA低甲基化的机制之一。
期刊:Cell Discovery
影响因子:12.5
doi:10.1038/celldisc.2016.7
Jia, Yuanhui; Li, Pishun; Fang, Lan; Zhu, Haijun; Xu, Liangliang; Cheng, Hao; Zhang, Junying; Li, Fei; Feng, Yan; Li, Yan; Li, Jialun; Wang, Ruiping; Du, James X; Li, Jiwen; Chen, Taiping; Ji, Hongbin; Han, Jackie; Yu, Wenqiang; Wu, Qihan; Wong, Jiemin
肿瘤
表观遗传
肿瘤免疫
DNA甲基化
信号转导
DNMT3A
