IL1β(+) macrophages promote intestinal fibrosis in Crohn's disease by secreting AREG to activate PI16(+) fibroblasts
IL1β(+)巨噬细胞通过分泌AREG激活PI16(+)成纤维细胞，从而促进克罗恩病中的肠道纤维化。
期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-026-07969-7
Xie, Hanlin; Wen, Xiaofeng; Ma, Tao; Wang, Lin; Guo, Yanxu; Liang, Guanzhan; Chen, Jing; Li, Ruibing; Pan, Yuxi; Xian, Zhenyu; Liu, Chuanyuan; Baihetiyaer, Yimamu; Tuersun, Abudumaimaitijiang; He, Xiaowen; Ke, Jia; He, Chunbo; Lian, Lei; Abulimiti, Abuduhalike; Hu, Tuo; Mo, Taiwei
巨噬细胞
成纤维细胞
AREG
巨噬细胞
细胞生物学
克罗恩病
免疫/内分泌
