Combined downregulation of TGF-β1 and GRP78 is responsible for overcoming acquired sorafenib resistance, which is initiated by rewiring the cell surface CD44-GRP78-IGF-1R signaling circuit.
TGF-β1 和 GRP78 的联合下调是克服获得性索拉非尼耐药性的原因，而这种耐药性是通过重新连接细胞表面 CD44-GRP78-IGF-1R 信号回路而启动的
期刊:Cancer Gene Therapy
影响因子:5
doi:10.1038/s41417-025-00937-1
Li Shengji, Oh Geun-Hyeok, Hong Jeong A, Choi Soojin, Kim Minseo, Kwon Hyeji, Ko Seung-Kyun, Park Sun Jun, Kim Hee Kyung, Choi Hye Jin, Song Jae J
