IRS4 is a PI3K-activating cancer dependency up-regulated through DNA rearrangements or epigenetic mechanisms in multiple solid tumors
IRS4 是一种 PI3K 激活的癌症依赖因子,在多种实体瘤中通过 DNA 重排或表观遗传机制上调。
期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.aeb3503
Banu, Khadija; Khan, Mohammad Aslam; Li, Sihan; Reynolds-Gagliano, Morgan; Wang, Xiaofei; Mobley, Robert J; Barnett, Kelly R; Wielgosz, Matthew M; Bauler, Matthew; Wincek, Christopher; Kodali, Kiran; Wang, Wei; Pagala, Vishwajeeth; High, Anthony A; Putnam, Daniel; Kotecha, Rishi S; Cheung, Laurence C; Ma, Xiaotu; Throm, Robert E; Pruett-Miller, Shondra M; Savic, Daniel; Brady, Samuel W