A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens
通过 CRISPR 基因编辑指导的基因筛选，发现了一类能够破坏整合素异二聚体稳定性的新型抑制剂。
期刊:Nature Structural & Molecular Biology
影响因子:12.5
doi:10.1038/s41594-024-01211-y
Nicole M Mattson ,Anthony K N Chan ,Kazuya Miyashita ,Elizaveta Mukhaleva ,Wen-Han Chang ,Lu Yang ,Ning Ma ,Yingyu Wang ,Sheela Pangeni Pokharel ,Mingli Li ,Qiao Liu ,Xiaobao Xu ,Renee Chen ,Priyanka Singh ,Leisi Zhang ,Zeinab Elsayed ,Bryan Chen ,Denise Keen ,Patrick Pirrotte ,Steven T Rosen ,Jianjun Chen ,Mark A LaBarge ,John E Shively ,Nagarajan Vaidehi ,Russell C Rockne ,Mingye Feng ,Chun-Wei Chen
