日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates RTFDC1 at the CASS4 locus

人类小胶质细胞模型中晚发性阿尔茨海默病 GWAS 信号的变异到功能映射表明 RTFDC1 与 CASS4 基因位点有关

Elizabeth A Burton, Mariana Argenziano, Kieona Cook, Molly Ridler, Sumei Lu, Chun Su, Elisabetta Manduchi, Sheridan H Littleton, Michelle E Leonard, Kenyaita M Hodge, Li-San Wang, Gerard D Schellenberg, Matthew E Johnson, Matthew C Pahl, James A Pippin, Andrew D Wells, Stewart A Anderson, Christophe

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease

蛋白磷酸酶 2A 和补体成分 4 与 APOE ε2 对阿尔茨海默病的保护作用有关

Gyungah R Jun, Yang You, Congcong Zhu, Gaoyuan Meng, Jaeyoon Chung, Rebecca Panitch, Junming Hu, Weiming Xia; Alzheimer's Disease Genetics Consortium; David A Bennett, Tatiana M Foroud, Li-San Wang, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard D Schellenberg, Rhoda Au, Kathryn

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease

综合多组学方法识别与阿尔茨海默病相关的表观遗传改变

Raffaella Nativio, Yemin Lan, Greg Donahue, Simone Sidoli, Amit Berson, Ananth R Srinivasan, Oksana Shcherbakova, Alexandre Amlie-Wolf, Ji Nie, Xiaolong Cui, Chuan He, Li-San Wang, Benjamin A Garcia, John Q Trojanowski, Nancy M Bonini, Shelley L Berger2

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

更正:全外显子组测序研究发现了与免疫反应和转录调控相关的新型罕见和常见阿尔茨海默病相关变异。

Bis, Joshua C; Jian, Xueqiu; Kunkle, Brian W; Chen, Yuning; Hamilton-Nelson, Kara L; Bush, William S; Salerno, William J; Lancour, Daniel; Ma, Yiyi; Renton, Alan E; Marcora, Edoardo; Farrell, John J; Zhao, Yi; Qu, Liming; Ahmad, Shahzad; Amin, Najaf; Amouyel, Philippe; Beecham, Gary W; Below, Jennifer E; Campion, Dominique; Cantwell, Laura; Charbonnier, Camille; Chung, Jaeyoon; Crane, Paul K; Cruchaga, Carlos; Cupples, L Adrienne; Dartigues, Jean-François; Debette, Stéphanie; Deleuze, Jean-François; Fulton, Lucinda; Gabriel, Stacey B; Genin, Emmanuelle; Gibbs, Richard A; Goate, Alison; Grenier-Boley, Benjamin; Gupta, Namrata; Haines, Jonathan L; Havulinna, Aki S; Helisalmi, Seppo; Hiltunen, Mikko; Howrigan, Daniel P; Ikram, M Arfan; Kaprio, Jaakko; Konrad, Jan; Kuzma, Amanda; Lander, Eric S; Lathrop, Mark; Lehtimäki, Terho; Lin, Honghuang; Mattila, Kari; Mayeux, Richard; Muzny, Donna M; Nasser, Waleed; Neale, Benjamin; Nho, Kwangsik; Nicolas, Gaël; Patel, Devanshi; Pericak-Vance, Margaret A; Perola, Markus; Psaty, Bruce M; Quenez, Olivier; Rajabli, Farid; Redon, Richard; Reitz, Christiane; Remes, Anne M; Salomaa, Veikko; Sarnowski, Chloe; Schmidt, Helena; Schmidt, Michael; Schmidt, Reinhold; Soininen, Hilkka; Thornton, Timothy A; Tosto, Giuseppe; Tzourio, Christophe; van der Lee, Sven J; van Duijn, Cornelia M; Valladares, Otto; Vardarajan, Badri; Wang, Li-San; Wang, Weixin; Wijsman, Ellen; Wilson, Richard K; Witten, Daniela; Worley, Kim C; Zhang, Xiaoling; Bellenguez, Celine; Lambert, Jean-Charles; Kurki, Mitja I; Palotie, Aarno; Daly, Mark; Boerwinkle, Eric; Lunetta, Kathryn L; Destefano, Anita L; Dupuis, Josée; Martin, Eden R; Schellenberg, Gerard D; Seshadri, Sudha; Naj, Adam C; Fornage, Myriam; Farrer, Lindsay A

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

poly(A) 结合蛋白 MSUT2 的活性决定了哺乳动物大脑对病理性 tau 的易感性

Jeanna M Wheeler, Pamela McMillan, Timothy J Strovas, Nicole F Liachko, Alexandre Amlie-Wolf, Rebecca L Kow, Ronald L Klein, Patricia Szot, Linda Robinson, Chris Guthrie, Aleen Saxton, Nicholas M Kanaan, Murray Raskind, Elaine Peskind, John Q Trojanowski, Virginia M Y Lee, Li-San Wang, C Dirk Keene,

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia

使用利巴韦林靶向 EIF4E 信号治疗婴儿急性淋巴细胞白血病

Karen A Urtishak #, Li-San Wang #, Biljana Culjkovic-Kraljacic #, James W Davenport, Patrizia Porazzi, Tiffaney L Vincent, David T Teachey, Sarah K Tasian, Jonni S Moore, Alix E Seif, Shenghao Jin, Jeffrey S Barrett, Blaine W Robinson, I-Ming L Chen, Richard C Harvey, Martin P Carroll, Andrew J Carr

Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease

阿尔茨海默病中正常衰老表观遗传景观的失调

Raffaella Nativio, Greg Donahue, Amit Berson, Yemin Lan, Alexandre Amlie-Wolf, Ferit Tuzer, Jon B Toledo, Sager J Gosai, Brian D Gregory, Claudio Torres, John Q Trojanowski, Li-San Wang, F Brad Johnson, Nancy M Bonini, Shelley L Berger

Chemical Modifications Mark Alternatively Spliced and Uncapped Messenger RNAs in Arabidopsis

化学修饰标记拟南芥中剪接和脱帽的信使 RNA

Lee E Vandivier, Rafael Campos, Pavel P Kuksa, Ian M Silverman, Li-San Wang, Brian D Gregory

Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin

因细胞质 TDP-43 表达导致的转录组变化揭示组蛋白转录本和核染色质的失调

Alexandre Amlie-Wolf, Paul Ryvkin, Rui Tong, Isabelle Dragomir, EunRan Suh, Yan Xu, Vivianna M Van Deerlin, Brian D Gregory, Linda K Kwong, John Q Trojanowski, Virginia M-Y Lee, Li-San Wang, Edward B Lee

Synaptic, transcriptional and chromatin genes disrupted in autism

自闭症中突触、转录和染色质基因的紊乱

De Rubeis, Silvia; He, Xin; Goldberg, Arthur P; Poultney, Christopher S; Samocha, Kaitlin; Cicek, A Erucment; Kou, Yan; Liu, Li; Fromer, Menachem; Walker, Susan; Singh, Tarinder; Klei, Lambertus; Kosmicki, Jack; Shih-Chen, Fu; Aleksic, Branko; Biscaldi, Monica; Bolton, Patrick F; Brownfeld, Jessica M; Cai, Jinlu; Campbell, Nicholas G; Carracedo, Angel; Chahrour, Maria H; Chiocchetti, Andreas G; Coon, Hilary; Crawford, Emily L; Curran, Sarah R; Dawson, Geraldine; Duketis, Eftichia; Fernandez, Bridget A; Gallagher, Louise; Geller, Evan; Guter, Stephen J; Hill, R Sean; Ionita-Laza, Juliana; Jimenz Gonzalez, Patricia; Kilpinen, Helena; Klauck, Sabine M; Kolevzon, Alexander; Lee, Irene; Lei, Irene; Lei, Jing; Lehtimäki, Terho; Lin, Chiao-Feng; Ma'ayan, Avi; Marshall, Christian R; McInnes, Alison L; Neale, Benjamin; Owen, Michael J; Ozaki, Noriio; Parellada, Mara; Parr, Jeremy R; Purcell, Shaun; Puura, Kaija; Rajagopalan, Deepthi; Rehnström, Karola; Reichenberg, Abraham; Sabo, Aniko; Sachse, Michael; Sanders, Stephan J; Schafer, Chad; Schulte-Rüther, Martin; Skuse, David; Stevens, Christine; Szatmari, Peter; Tammimies, Kristiina; Valladares, Otto; Voran, Annette; Li-San, Wang; Weiss, Lauren A; Willsey, A Jeremy; Yu, Timothy W; Yuen, Ryan K C; Cook, Edwin H; Freitag, Christine M; Gill, Michael; Hultman, Christina M; Lehner, Thomas; Palotie, Aaarno; Schellenberg, Gerard D; Sklar, Pamela; State, Matthew W; Sutcliffe, James S; Walsh, Christiopher A; Scherer, Stephen W; Zwick, Michael E; Barett, Jeffrey C; Cutler, David J; Roeder, Kathryn; Devlin, Bernie; Daly, Mark J; Buxbaum, Joseph D