日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors

呼吸链复合物II泛醌结合位点及其抑制剂的晶体学研究

Huang, Li-Shar; Lümmen, Peter; Berry, Edward A

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

3-硝基丙酸是线粒体呼吸的自杀抑制剂,经复合物 II 氧化后,与酶活性位点的催化碱基精氨酸形成共价加合物

Li-shar Huang, Gang Sun, David Cobessi, Andy C Wang, John T Shen, Eric Y Tung, Vernon E Anderson, Edward A Berry

Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state

对配体与复合物 II 二羧酸位点的结合进行晶体学研究,并确定“草酰乙酸抑制”状态下的配体。

Huang, Li-Shar; Shen, John T; Wang, Andy C; Berry, Edward A

Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern

呼吸链抑制剂抗霉素与线粒体bc1复合物的结合:新的晶体结构揭示了改变的分子内氢键模式

Huang, Li-Shar; Cobessi, David; Tung, Eric Y; Berry, Edward A