3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme
3-硝基丙酸是线粒体呼吸的自杀抑制剂,经复合物 II 氧化后,与酶活性位点的催化碱基精氨酸形成共价加合物
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M511270200
Li-shar Huang, Gang Sun, David Cobessi, Andy C Wang, John T Shen, Eric Y Tung, Vernon E Anderson, Edward A Berry