Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands

定点体外免疫可产生完整的人类单克隆 IgG4 lambda，该抗体可特异性结合 CTLA-4 (CD152) 的 CDR2 区域，而不会干扰天然配体的结合