日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Targeting SPAK suppresses progression and averts an immune exhaustive microenvironment in hepatocellular carcinoma

靶向SPAK可抑制肝细胞癌的进展并避免免疫耗竭的微环境。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-68156-8
Pan, Yonglong; Zeng, Chenglong; He, Yi; Chang, Ruizhi; Wu, Jingjing; Yuan, Chaoyi; Li, Haisen; Su, Chen; Han, Mengzhen; Li, Pengcheng; Li, Xinxin; Zhang, Hongwei; Liu, Furong; Liang, Huifang; Li, Zifu; Wu, Mi; Xia, Limin; Liu, Jianfeng; Chen, Xiaoping; Zhang, Wanguang; Zhang, Bixiang; Ding, Ze-Yang
细胞生物学
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2026
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Tumor-Induced Rewiring of Splenic Niches: from Immune Organ to Cancer Accomplice

肿瘤诱导的脾脏微环境重塑：从免疫器官到癌症帮凶

期刊:International Journal of Biological Sciences
影响因子:10
doi:10.7150/ijbs.127169
Yuan, Tong; Liu, Junjie; Zhang, Chunyu; Lv, Xing; Tan, Guan; Xue, Lin; Zhang, Erlei; Liang, Huifang; Huang, Zhiyong
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2026
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ITLN1, orchestrated by the IFNγ-IRF1 axis, suppresses hepatocellular carcinoma proliferation via ERK1/2 activation

ITLN1 在 IFNγ-IRF1 轴的调控下，通过激活 ERK1/2 抑制肝细胞癌的增殖。

期刊:Translational Oncology
影响因子:4.1
doi:10.1016/j.tranon.2025.102600
Yuan, Tong; Liu, Junjie; Zhu, Ronghua; Li, Jiang; Huang, Zhiyong; Liang, Huifang; Tao, Haisu; Zhang, Erlei
肿瘤
肿瘤免疫
信号转导
IFNγ
MAPK/ERK
细胞生物学
发表日期：2026
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SPP1+ Macrophages and the Orchestration of Spatially Organized Immunosuppression in Cancer

SPP1+巨噬细胞与癌症中空间组织免疫抑制的调控

期刊:Biomedicines
影响因子:3.9
doi:10.3390/biomedicines14020294
Li, Fanshu; Xu, Dafeng; Tang, Zhen; Lai, Yangfeng; Liu, Qiumeng; Liang, Huifang; Dong, Hanhua; Song, Jia
巨噬细胞
肿瘤
肿瘤免疫
巨噬细胞
信号转导
细胞生物学
免疫/内分泌
发表日期：2026
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Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.

辛伐他汀可克服 AKT 过度激活的肝内胆管癌中 pPCK1-pLDHA-SPRINGlac 轴介导的铁死亡和化疗免疫疗法耐药性

期刊:Cancer Communications
影响因子:24.9
doi:10.1002/cac2.70036
Zhu Jinghan, Xiong Yixiao, Zhang Yuxin, Liang Huifang, Cheng Kun, Lu Yuanxiang, Cai Guangzhen, Wu Yang, Fan Yunhui, Chen Xiaoping, Zhu Hong, Ding Zeyang, Zhang Wanguang
肿瘤
PI3K/Akt
铁死亡
发表日期：2025
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MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation

MET通过促进TRIB3介导的FOXO1降解来促进肝细胞癌的发生发展。

期刊:Clinical and Molecular Hepatology
影响因子:16.9
doi:10.3350/cmh.2024.1163
Wang, Tiantian; Rao, Dean; Fu, Chenan; Sun, Zhoubin; Luo, Yiming; Lu, Junli; Jin, Jie; Li, Han; Fan, Feimu; Liang, Huifang; Huang, Wenjie; Xia, Limin
FOXO1
MET
肿瘤
细胞生物学
肿瘤免疫
TRIB3
发表日期：2025
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Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma

短期饥饿可通过重塑肝细胞癌中的肿瘤相关巨噬细胞来增强抗PD-L1疗法的疗效

期刊:Hepatology
影响因子:15.8
doi:10.1097/HEP.0000000000001244
Cheng, Kun; Cai, Ning; Yang, Xing; Li, Danfeng; Zhu, Jinghan; Yang, Hui Yuan; Liu, Sha; Ning, Deng; Liang, Huifang; Zhao, Jianping; Zhang, Zhanguo; Zhang, Wanguang
巨噬细胞
肿瘤
肿瘤免疫
巨噬细胞
PD-L1
细胞生物学
免疫/内分泌
发表日期：2025
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Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT

破坏细胞核内CCDC137介导的LZTS2和β-TrCP相互作用可通过β-catenin和AKT抑制肝细胞癌的发生发展。

期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-024-01328-z
Xu, Lei; Liu, Qiumeng; Liu, Hailing; Fan, Feimu; Li, Pengcheng; Yue, Shiwei; Mo, Jie; Liu, Zhicheng; Dong, Renshun; Zhang, Xuewu; Dong, Hanhua; Liang, Huifang; Chen, Xiaoping; Zhang, Bixiang; Chen, Lin; Chen, Jin
肿瘤
肿瘤免疫
LZTS2
细胞生物学
AKT
发表日期：2025
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CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression.

CKAP4 在肝细胞癌中的作用：竞争性 RETREG1/FAM134B 结合、网状吞噬调控和癌症进展

期刊:Autophagy
影响因子:14.3
doi:10.1080/15548627.2024.2435236
Mo Jie, Su Chen, Li Pengcheng, Yang Zhenhua, Tao Ran, Liu Qiumeng, Yuan Chaoyi, Xu Lei, Ge Qianyun, Ning Deng, Liang Huifang, Zhu Haidan, Luo Yan, Chen Xiaoping, Chen Jin, Zhang Bixiang
细胞生物学
肿瘤免疫
发表日期：2025
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PARK7-driven IGF2BP3-K76 lactylation mediates ferroptosis and HAIC resistance in hepatocellular carcinoma

PARK7驱动的IGF2BP3-K76乳酸化介导肝细胞癌中的铁死亡和HAIC抵抗

期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2025.103869
Zhu, Zhiwen; Xia, Xinyu; Lu, Yuanxiang; Li, Danfeng; He, Xincheng; Zhang, Baohua; Xiong, Ge; Zhang, Wanguang; Liang, Huifang; Zhu, Hong
肿瘤
肿瘤免疫
铁死亡
乳酸化
细胞生物学
发表日期：2025
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