日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Blocking XIAP:CASP7-p19 selectively induces apoptosis of CASP3/DR malignancies by a novel reversible small molecule

一种新型可逆小分子阻断XIAP:CASP7-p19可选择性地诱导CASP3/DR恶性肿瘤细胞凋亡。

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07774-y
Chen, Shih-Hsun; Wu, Szu-Ying; Chang, Yun-Xun; Lui, En-Ning; Chang, Chih-Kang; Lin, Sheng-Wei; Hsiao, Michael; Yang, Jinn-Moon; Liang, Po-Huang
CASP7
肿瘤
SP3
表观遗传
肿瘤免疫
凋亡
XIAP
细胞生物学
肿瘤细胞
CASP3
SP7
发表日期：2025
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Green Synthesis of Tetrahydropyrazino[2,1-a:5,4-a']diisoquinolines as SARS-CoV-2 Entry Inhibitors

绿色合成四氢吡嗪并[2,1-a:5,4-a']二异喹啉类化合物作为SARS-CoV-2入侵抑制剂

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.4c08640
Palla, Sowndarya; Palla, Srinivasa Rao; Liu, Jia-Jin; Chao, Tai-Ling; Lee, Ting-Hui; Kavala, Veerababurao; Liu, I-Chen; Wang, Lily Hui-Ching; Chang, Sui-Yuan; Yao, Ching-Fa; Liang, Po-Huang
SARS-CoV-2
发表日期：2025
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Identification of non-covalent 3C-like protease inhibitors against severe acute respiratory syndrome coronavirus-2 via virtual screening of a Korean compound library

通过对韩国化合物库进行虚拟筛选，鉴定针对严重急性呼吸综合征冠状病毒2的非共价3C样蛋白酶抑制剂

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2021.128067
Lee, Joo-Youn; Kuo, Chih-Jung; Shin, Jin Soo; Jung, Eunhye; Liang, Po-Huang; Jung, Young-Sik
微生物学
发表日期：2021
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Highly sensitive fluorogenic sensing of L-Cysteine in live cells using gelatin-stabilized gold nanoparticles decorated graphene nanosheets

利用明胶稳定的金纳米粒子修饰的石墨烯纳米片对活细胞中的L-半胱氨酸进行高灵敏度荧光传感

期刊:Sensors and Actuators B-Chemical
影响因子:7.7
doi:10.1016/j.snb.2017.12.028
Thirumalraj, Balamurugan; Dhenadhayalan, Namasivayam; Chen, Shen-Ming; Liu, Yan-Jin; Chen, Tse-Wei; Liang, Po-Huang; Lin, King-Chuen
细胞生物学
IF
发表日期：2018
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Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum

热纤维梭菌双功能纤维素酶/木聚糖酶的生化特性及结构分析

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M114.604454
Yuan, Shuo-Fu; Wu, Tzu-Hui; Lee, Hsiao-Lin; Hsieh, Han-Yu; Lin, Wen-Ling; Yang, Barbara; Chang, Chih-Kang; Li, Qian; Gao, Jian; Huang, Chun-Hsiang; Ho, Meng-Chiao; Guo, Rey-Ting; Liang, Po-Huang
发表日期：2015
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Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms

大肠杆菌配体结合的辛烯基焦磷酸合酶的晶体结构揭示了其催化和链长决定机制。

期刊:Proteins-Structure Function and Bioinformatics
影响因子:2.8
doi:10.1002/prot.24618
Han, Xu; Chen, Chun-Chi; Kuo, Chih-Jung; Huang, Chun-Hsiang; Zheng, Yingying; Ko, Tzu-Ping; Zhu, Zhen; Feng, Xinxin; Wang, Ke; Oldfield, Eric; Wang, Andrew H-J; Liang, Po-Huang; Guo, Rey-Ting; Ma, Yanhe
发表日期：2015
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Structures of exoglucanase from Clostridium cellulovorans: cellotetraose binding and cleavage

梭菌属纤维梭菌外切葡聚糖酶的结构：纤维四糖的结合和切割

期刊:Acta Crystallographica Section F-Structural Biology Communications
影响因子:1.1
doi:10.1107/S2053230X15015915
Tsai, Li Chu; Amiraslanov, Imamaddin; Chen, Hung Ren; Chen, Yun Wen; Lee, Hsiao Lin; Liang, Po Huang; Liaw, Yen Chywan
发表日期：2015
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Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis

结核分枝杆菌结核菌素合成酶和癸烯基二磷酸合成酶的结构及抑制

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/ja413127v
Chan, Hsiu-Chien; Feng, Xinxin; Ko, Tzu-Ping; Huang, Chun-Hsiang; Hu, Yumei; Zheng, Yingying; Bogue, Shannon; Nakano, Chiaki; Hoshino, Tsutomu; Zhang, Lilan; Lv, Pin; Liu, Wenting; Crick, Dean C; Liang, Po-Huang; Wang, Andrew H-J; Oldfield, Eric; Guo, Rey-Ting
发表日期：2014
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Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties

苄基香草醛与苯并咪唑结构的结合可增强DNA结合能力，从而提高抗白血病活性。

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0080983
Al-Mudaris, Zena A; Majid, Aman S A; Ji, Dan; Al-Mudarris, Ban A; Chen, Shih-Hsun; Liang, Po-Huang; Osman, Hasnah; Jamal Din, Shah Kamal Khan; Abdul Majid, Amin M S
白血病
发表日期：2013
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Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes

从不同复合物的晶体结构中深入了解抗生素合成酶 MoeO5 的作用机制

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.201108002
Ren, Feifei; Ko, Tzu-Ping; Feng, Xinxin; Huang, Chun-Hsiang; Chan, Hsiu-Chien; Hu, Yumei; Wang, Ke; Ma, Yanhe; Liang, Po-Huang; Wang, Andrew H-J; Oldfield, Eric; Guo, Rey-Ting
发表日期：2012
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