日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Antisense oligonucleotide-mediated upregulation of Jag1 ameliorates liver disease phenotypes in a mouse model of Alagille syndrome

反义寡核苷酸介导的 Jag1 上调可改善阿拉吉勒综合征小鼠模型的肝脏疾病表型。

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2025.102694
Zhang, Lingdi; Niknejad, Nima; Li, Jian; Peng, Lansha; Jain, Surendra; Steiner, Derek; Thai, Rich; Yu, Xing Xian; Wang, Yanfeng; Liang, Xue-Hai
发表日期：2025
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Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1

人类DBHS蛋白NONO和PSPC1二聚化和核酸结合的结构基础

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkab1216
Knott, Gavin J; Chong, Yee Seng; Passon, Daniel M; Liang, Xue-Hai; Deplazes, Evelyne; Conte, Maria R; Marshall, Andrew C; Lee, Mihwa; Fox, Archa H; Bond, Charles S
PSPC
NONO
PSPC1
发表日期：2022
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RNA modifications can affect RNase H1-mediated PS-ASO activity

RNA修饰可影响RNase H1介导的PS-ASO活性

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2022.05.024
Doxtader Lacy, Katelyn A; Liang, Xue-Hai; Zhang, Lingdi; Crooke, Stanley T
发表日期：2022
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Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides

位点特异性引入2',5'-连接的核酸可增强反义寡核苷酸的治疗效果

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.1c00072
Prakash, Thazha P; Yu, Jinghua; Shen, Wen; De Hoyos, Cheryl Li; Berdeja, Andres; Gaus, Hans; Liang, Xue-Hai; Crooke, Stanley T; Seth, Punit P
发表日期：2021
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Antisense technology: A review

反义技术：综述

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2021.100416
Crooke, Stanley T; Liang, Xue-Hai; Baker, Brenda F; Crooke, Rosanne M
发表日期：2021
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Phosphorothioate modified oligonucleotide-protein interactions

硫代磷酸酯修饰的寡核苷酸-蛋白质相互作用

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaa299
Crooke, Stanley T; Vickers, Timothy A; Liang, Xue-Hai
发表日期：2020
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Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

M6PR介导的高尔基体-内体运输促进反义寡核苷酸从内体释放。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkz1171
Liang, Xue-Hai; Sun, Hong; Hsu, Chih-Wei; Nichols, Joshua G; Vickers, Timothy A; De Hoyos, Cheryl L; Crooke, Stanley T
发表日期：2020
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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

通过位点特异性地用烷基膦酸酯键取代硫代磷酸酯键，可以调节间隙型反义寡核苷酸（ASO）与细胞蛋白的相互作用，从而增强其治疗效果。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkz247
Migawa, Michael T; Shen, Wen; Wan, W Brad; Vasquez, Guillermo; Oestergaard, Michael E; Low, Audrey; De Hoyos, Cheryl L; Gupta, Ruchi; Murray, Susan; Tanowitz, Michael; Bell, Melanie; Nichols, Joshua G; Gaus, Hans; Liang, Xue-Hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P
细胞生物学
发表日期：2019
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mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

反义寡核苷酸可通过“no-go decay”途径降低mRNA水平。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkz500
Liang, Xue-Hai; Nichols, Joshua G; Hsu, Chih-Wei; Vickers, Timothy A; Crooke, Stanley T
发表日期：2019
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COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways

COPII囊泡可通过促进寡核苷酸从内吞途径释放，从而影响反义寡核苷酸的活性。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gky841
Liang, Xue-Hai; Sun, Hong; Nichols, Joshua G; Allen, Nickolas; Wang, Shiyu; Vickers, Timothy A; Shen, Wen; Hsu, Chih-Wei; Crooke, Stanley T
囊泡
发表日期：2018
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