日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Extended stop codon context predicts nonsense codon readthrough efficiency in human cells

延长的终止密码子上下文可预测人类细胞中的无义密码子读通效率

Kotchaphorn Mangkalaphiban, Lianwu Fu, Ming Du, Kari Thrasher, Kim M Keeling, David M Bedwell, Allan Jacobson

Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection

感染 SARS-CoV-2 的叙利亚仓鼠的粘液纤毛运输缺陷和疾病进展

Qian Li, Kadambari Vijaykumar, Scott E Phillips, Shah S Hussain, Nha V Huynh, Courtney M Fernandez-Petty, Jacelyn E Peabody Lever, Jeremy B Foote, Janna Ren, Javier Campos-Gómez, Farah Abou Daya, Nathaniel W Hubbs, Harrison Kim, Ezinwanne Onuoha, Evan R Boitet, Lianwu Fu, Hui Min Leung, Linhui Yu, T

The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators

合成氨基糖苷 ELX-02 可诱导 G550X-CFTR 读通,产生超功能蛋白质,而 CFTR 调节剂可进一步增强该蛋白质的功能

Jianguo Chen, Kari Thrasher, Lianwu Fu, Wei Wang, Soheil Aghamohammadzadeh, Hui Wen, Liping Tang, Kim M Keeling, Emily Falk Libby, David M Bedwell, Steven M Rowe

RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay

RNA 结合蛋白 PTBP1 和 HNRNPL 调节 CFTR mRNA 衰变

Amna Siddiqui, Arpit Saxena, Joshua Echols, Viktoria Havasi, Lianwu Fu, Kim M Keeling

Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells

通过 Prime 编辑介导纠正 iPSC 和衍生的气道上皮细胞中的 CFTR W1282X 突变

Chao Li, Zhong Liu, Justin Anderson, Zhongyu Liu, Liping Tang, Yao Li, Ning Peng, Jianguo Chen, Xueming Liu, Lianwu Fu, Tim M Townes, Steven M Rowe, David M Bedwell, Jennifer Guimbellot, Rui Zhao

Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection

感染 SARS-CoV-2 的叙利亚仓鼠的粘液纤毛运输缺陷和疾病进展

Qian Li, Kadambari Vijaykumar, Scott E Philips, Shah S Hussain, Van N Huynh, Courtney M Fernandez-Petty, Jacelyn E Peabody Lever, Jeremy B Foote, Janna Ren, Javier Campos-Gómez, Farah Abou Daya, Nathaniel W Hubbs, Harrison Kim, Ezinwanne Onuoha, Evan R Boitet, Lianwu Fu, Hui Min Leung, Linhui Yu, Th

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

通过 eRF1 消耗来诱导 CFTR 无义突变翻译读通的小分子

Jyoti Sharma #, Ming Du #, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J Bostwick, Corinne E Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric

G551D mutation impairs PKA-dependent activation of CFTR channel that can be restored by novel GOF mutations

G551D 突变会损害 PKA 依赖的 CFTR 通道激活,而新的 GOF 突变可以恢复这种激活

Wei Wang, Lianwu Fu, Zhiyong Liu, Hui Wen, Andras Rab, Jeong S Hong, Kevin L Kirk, Steven M Rowe

Chymase uptake by cardiomyocytes results in myosin degradation in cardiac volume overload

心肌细胞摄取糜蛋白酶导致心脏容量超负荷时肌球蛋白降解

Pamela C Powell, Chih-Chang Wei, Lianwu Fu, Betty Pat, Wayne E Bradley, James F Collawn, Louis J Dell'Italia

Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure

在容量超负荷心力衰竭中,结蛋白丢失和线粒体损伤先于左心室收缩衰竭

Jason L Guichard, Michael Rogowski, Giulio Agnetti, Lianwu Fu, Pamela Powell, Chih-Chang Wei, James Collawn, Louis J Dell'Italia