Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis.
组蛋白乳酸化增强 GCLC 表达,从而通过抑制铁死亡促进结直肠癌干细胞的化疗耐药性
期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07498-z
Deng Jiao, Li Yangkun, Yin Lanlan, Liu Shuang, Li Yanqi, Liao Wancheng, Mu Lei, Luo Xuelai, Qin Jichao