Dihydroorotate dehydrogenase inhibition activates STING pathway and pyroptosis to enhance NK cell-dependent tumor immunotherapy.
二氢乳清酸脱氢酶抑制可激活 STING 通路和细胞焦亡，从而增强 NK 细胞依赖性肿瘤免疫疗法。
期刊:Molecular Biomedicine
影响因子:10.1
doi:10.1186/s43556-025-00339-7
Hai Yongrui, Lin Ruizhuo, Liao Weike, Fu Shuo, Fan Renming, Ding Guiquan, Zhuang Junyan, Zhang Bingjie, Liu Yi, Song Junke, Wei Gaofei
肿瘤
表观遗传
肿瘤免疫
信号转导
STING
焦亡
细胞生物学
NK 细胞
免疫/内分泌
