日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Proximity-Induced Rewiring of Oncogenic Kinase Triggers Apoptosis

邻近诱导的致癌激酶重编程触发细胞凋亡

Merz, Manuel L; Shoba, Veronika M; Pergu, Rajaiah; Severance, Zachary C; Munkanatta Godage, Dhanushka N P; Deb, Arghya; Kwok, Hui Si; Singh, Prashant; Singh, Sameek; Allen, Jonathan B; Tian, Wenzhi; Gosavi, Pallavi M; Chaudhary, Santosh K; Anokhina, Viktoriya; Weisberg, Ellen L; Payne, N Connor; He, Yao; Dhaliwal, Rohil; Osadchey, Reilly; Shekhar, Mrinal; Mazitschek, Ralph; Rees, Matthew G; Roth, Jennifer A; Cui, Qiang; Griffin, James D; Liau, Brian B; Choudhary, Amit

Nanoscaled, Fully Automated Hydrogen/Deuterium Exchange for Analysis of Macromolecular Assemblies Reaching the MDa Scale

用于分析兆道尔顿级大分子组装体的纳米级全自动氢/氘交换技术

Raval, Shaunak; Shi, Yuqi; Morriss, Julia W; Ivanov, Alexander R; Coales, Stephen J; Aphasizheva, Inna; Aphasizhev, Ruslan; Liau, Brian B; Carr, Steven A; Papanastasiou, Malvina

A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition

PAF1与ENL/AF9 YEATS抑制之间的化学遗传相互作用

Barta, Paige A; Garnar-Wortzel, Leopold; Bishop, Timothy R; Hayward, Rachel E; Hargis, Lauren M; Shaum, James B; Kwok, Hui Si; Liau, Brian B; Cravatt, Benjamin F; Erb, Michael A

Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase.

将 CRISPR 扫描与使用双链 DNA 脱氨酶的靶向染色质可及性分析相结合。

Roh Heejin, Shen Simon P, Hu Yan, Kwok Hui Si, Siegenfeld Allison P, Lee Ceejay, Zepeda Marcanthony U, Guo Chun-Jie, Roseman Shelby A, Comenho Caroline, Sankaran Vijay G, Buenrostro Jason D, Liau Brian B

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.

共价加合物 Grob 断裂是 LSD1 去甲基酶特异性抑制剂作用机制和耐药性的基础

Waterbury Amanda L, Caroli Jonatan, Zhang Olivia, Tuttle Paloma R, Liu Chao, Li Jiaming, Park Ji Sung, Hoenig Samuel M, Barone Marco, Furui Airi, Mattevi Andrea, Liau Brian B

Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1.

通过改造赖氨酸去甲基酶 LSD1 来解耦组蛋白修饰串扰

Lee Kwangwoon, Barone Marco, Waterbury Amanda L, Jiang Hanjie, Nam Eunju, DuBois-Coyne Sarah E, Whedon Samuel D, Wang Zhipeng A, Caroli Jonatan, Neal Katherine, Ibeabuchi Brian, Dhoondia Zuzer, Kuroda Mitzi I, Liau Brian B, Beck Samuel, Mattevi Andrea, Cole Philip A

DNA methylation insulates genic regions from CTCF loops near nuclear speckles.

DNA甲基化使基因区域与核斑点附近的CTCF环隔离

Roseman Shelby A, Siegenfeld Allison P, Lee Ceejay, Lue Nicholas Z, Waterbury Amanda L, Liau Brian B

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis.

磷酸化诱导嵌合体重塑致癌激酶以触发细胞凋亡

Merz Manuel L, Shoba Veronika M, Pergu Rajaiah, Severance Zachary C, Munkanatta Godage Dhanushka N P, Deb Arghya, Kwok Hui Si, Singh Prashant, Singh Sameek, Allen Jonathan B, Tian Wenzhi, Gosavi Pallavi M, Chaudhary Santosh K, Anokhina Viktoriya, Weisberg Ellen L, Payne N Connor, He Yao, Osadchey Reilly, Shekhar Mrinal, Mazitschek Ralph, Rees Matthew G, Roth Jennifer A, Cui Qiang, Griffin James D, Liau Brian B, Choudhary Amit

Asymmetric Engagement of Dimeric CRL3 (KBTBD4) by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes

分子胶UM171与二聚体CRL3(KBTBD4)的不对称结合促进HDAC1/2复合物的降解

Yeo, Megan Jr; Zhang, Olivia; Xie, Xiaowen; Nam, Eunju; Payne, Neil Connor; Gosavi, Pallavi M; Kwok, Hui Si; Iram, Irtiza; Lee, Ceejay; Li, Jiaming; Chen, Nicholas J; Jiang, Hanjie; Wang, Zhipeng A; Lee, Kwangwoon; Mao, Haibin; Harry, Stefan A; Barakat, Idris A; Takahashi, Mariko; Waterbury, Amanda L; Barone, Marco; Mattevi, Andrea; Bar-Peled, Liron; Cole, Philip A; Mazitschek, Ralph; Liau, Brian B; Zheng, Ning

Base editor screens for in situ mutational scanning at scale

用于大规模原位突变扫描的基础编辑器筛选器

Lue, Nicholas Z; Liau, Brian B