Abrogation of HnRNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8+ T cell-mediated ferroptosis in castration-resistant prostate cancer
HnRNP L 的缺失可通过降低 PD-L1 表达和促进 CD8+ T 细胞介导的铁死亡来增强抗 PD-1 疗法在去势抵抗性前列腺癌中的疗效。
期刊:Acta Pharmaceutica Sinica B
影响因子:14.7
doi:10.1016/j.apsb.2021.07.016
Xumin Zhou,Libin Zou,Hangyu Liao,Junqi Luo,Taowei Yang,Jun Wu,Wenbin Chen,Kaihui Wu,Shengren Cen,Daojun Lv,Fangpeng Shu,Yu Yang,Chun Li,Bingkun Li,Xiangming Mao
前列腺癌
细胞生物学
肿瘤
PD-L1
CD8
PD-1
铁死亡
