日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling

中风风险基因Foxf2通过Tie2信号通路维持脑内皮细胞功能。

Todorov-Völgyi, Katalin; González-Gallego, Judit; Müller, Stephan A; Todorov, Mihail Ivilinov; Seker, Fatma Burcu; Frerich, Simon; Cernilogar, Filippo M; Schröger, Luise; Malik, Rainer; Cao, Jiayu; Llovera, Gemma; Roth, Stefan; Schillinger, Ulrike; Schifferer, Martina; Reyahi, Azadeh; Crusius, Dennis; Pedro, Liliana D; Simons, Mikael; Carlsson, Peter; Ertürk, Ali; Liesz, Arthur; Schotta, Gunnar; Plesnila, Nikolaus; Lichtenthaler, Stefan F; Paquet, Dominik; Dichgans, Martin

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动剂的疗效至关重要。

Feiten, Astrid F; Dahm, Kilian; Schlepckow, Kai; van Lengerich, Bettina; Suh, Jung H; Reifschneider, Anika; Wefers, Benedikt; Bartos, Laura M; Wind-Mark, Karin; de Weerd, Lis; Ulas, Thomas; De-Domenico, Elena; Grundschöttel, Pia; Paulusch, Stefan; Tast, Benjamin; Honda, Tamisa; Müller, Stephan A; Becker, Matthias; Khalin, Igor; Ricci, Alessio; Liesz, Arthur; Brunner, Bettina; Krenner, Claudia; Buschmann, Katrin; Nuscher, Brigitte; Spieth, Lena; Junker, Niklas; Berghoff, Stefan A; Davis, Sonnet S; Neher, Jonas J; Wurst, Wolfgang; Plesnila, Nikolaus; Lewcock, Joseph W; Simons, Mikael; Lichtenthaler, Stefan F; Di Paolo, Gilbert; Brendel, Matthias; Capell, Anja; Monroe, Kathryn M; Schultze, Joachim L; Haass, Christian

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

VMAT2 功能障碍会损害囊泡多巴胺的摄取,从而导致 DJ-1 相关的帕金森神经元中多巴胺的氧化和 α-突触核蛋白病理。

Heger Leonie M, Gubinelli Francesco, Huber Andreas J, Cardona-Alberich Aida, Rovere Matteo, Matti Ulf, Müller Stephan A, Nagaraja Sankarshana R, Jaschkowitz Lena, Schifferer Martina, Wurst Wolfgang, Lichtenthaler Stefan F, Behrends Christian, Sambandan Sivakumar, Burbulla Lena F

Multi-platform integration of brain and CSF proteomes reveals biomarker panels for Alzheimer's disease

脑组织和脑脊液蛋白质组的多平台整合揭示了阿尔茨海默病的生物标志物组合

Tsai, Wei-Yun; Giesbertz, Pieter; Breimann, Stephan; Lichtenthaler, Stefan; Frishman, Dmitrij

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

BACE1 通过酶促和非酶促作用调节睡眠-觉醒周期。

Heininger Hannah, Feng Xiao, Altunkaya Alp, Zheng Fang, Stockinger Florian, Wefers Benedikt, Müller Stephan A, Giesbertz Pieter, Tschirner Sarah K, Shqau Dorina, Adelsberger Helmuth, Ponomarenko Alexey, Fenzl Thomas, Alzheimer Christian, Lichtenthaler Stefan F, Huth Tobias

Multicenter evaluation of label-free quantification in human plasma on a high dynamic range benchmark set

在高动态范围基准数据集上对人血浆中无标记定量方法进行多中心评估

Distler, Ute; Yoo, Han Byul; Kardell, Oliver; Hein, Dana; Sielaff, Malte; Scherer, Marian; Jozefowicz, Anna M; Leps, Christian; Gomez-Zepeda, David; von Toerne, Christine; Merl-Pham, Juliane; Barth, Teresa K; Tüshaus, Johanna; Giesbertz, Pieter; Müller, Torsten; Kliewer, Georg; Aljakouch, Karim; Helm, Barbara; Unger, Henry; Frey, Dario L; Helm, Dominic; Schwarzmüller, Luisa; Popp, Oliver; Qin, Di; Wudy, Susanne I; Sinn, Ludwig Roman; Mergner, Julia; Ludwig, Christina; Imhof, Axel; Kuster, Bernhard; Lichtenthaler, Stefan F; Krijgsveld, Jeroen; Klingmüller, Ursula; Mertins, Philipp; Coscia, Fabian; Ralser, Markus; Mülleder, Michael; Hauck, Stefanie M; Tenzer, Stefan

Charting γ-secretase substrates by explainable AI.

利用可解释人工智能绘制 α-分泌酶底物图

Breimann Stephan, Kamp Frits, Basset Gabriele, Abou-Ajram Claudia, Güner Gökhan, Yanagida Kanta, Okochi Masayasu, Müller Stephan A, Lichtenthaler Stefan F, Langosch Dieter, Frishman Dmitrij, Steiner Harald

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease

单等位基因 TYROBP 缺失是阿尔茨海默病的一个新的风险因素

Henna Martiskainen # ,Roosa-Maria Willman # ,Päivi Harju ,Sami Heikkinen ,Mette Heiskanen ,Stephan A Müller ,Rosa Sinisalo ,Mari Takalo ,Petra Mäkinen ,Teemu Kuulasmaa ,Viivi Pekkala ,Ana Galván Del Rey ,Sini-Pauliina Juopperi ,Heli Jeskanen ,Inka Kervinen ,Kirsi Saastamoinen ,Sami V Heikkinen ,Mitja I Kurki ,Jarkko Marttila ,Petri I Mäkinen ,Hannah Rostalski ,Tomi Hietanen ,Tiia Ngandu ,Jenni Lehtisalo ,Céline Bellenguez ,Jean-Charles Lambert ,Christian Haass ,Juha Rinne ,Juhana Hakumäki ,Tuomas Rauramaa ,Johanna Krüger ,Hilkka Soininen ,Annakaisa Haapasalo ,Stefan F Lichtenthaler ,Ville Leinonen ,Eino Solje ,Mikko Hiltunen

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques

早期干预抗Aβ免疫疗法可减轻小胶质细胞活化,而不会导致残余斑块处的细胞耗竭。

Lis de Weerd ,Selina Hummel ,Stephan A Müller ,Iñaki Paris ,Thomas Sandmann ,Marie Eichholtz ,Robin Gröger ,Amelie L Englert ,Stephan Wagner ,Connie Ha ,Sonnet S Davis ,Valerie Warkins ,Dan Xia ,Brigitte Nuscher ,Anna Berghofer ,Marvin Reich ,Astrid F Feiten ,Kai Schlepckow ,Michael Willem ,Stefan F Lichtenthaler ,Joseph W Lewcock ,Kathryn M Monroe ,Matthias Brendel ,Christian Haass

Neuropathy-associated Tecpr2 mutation knock-in mice reveal endolysosomal loss of function phenotypes in neurons and microglia

神经病变相关的Tecpr2突变敲入小鼠揭示了神经元和小胶质细胞中内溶酶体功能丧失的表型。

Bhattacharya, Debjani; da Silva-Buttkus, Patricia; Nalbach, Karsten; Cheng, Lizhen; Garrett, Lillian; Irmler, Martin; Kislinger, Georg; Werner, Georg; Rodde, Ramona; Lengger, Christoph; Beckers, Johannes; Zimprich, Annemarie; Hölter, Sabine M; Gailus-Durner, Valerie; Fuchs, Helmut; Hrabe de Angelis, Martin; Wefers, Benedikt; Wurst, Wolfgang; Brill, Monika S; Schifferer, Martina; Lichtenthaler, Stefan F; Behrends, Christian