日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

CRISPR knockout screens reveal JUN as the master mediator of resistance to MAPK inhibition in KRAS-mutant pancreatic cancer

CRISPR基因敲除筛选揭示JUN是KRAS突变型胰腺癌中MAPK抑制剂耐药性的主要介质

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:12.8
doi:10.1186/s13046-025-03616-z
Mulero-Sánchez, Antonio; Bosma, Astrid; Visuvasam, Bonifiya; Pouliopoulou, Niki; van de Ven, Marieke; Proost, Natalie; Boeije, Manon; Lieftink, Cor; Beijersbergen, Roderick; Bernards, Rene; Mainardi, Sara
肿瘤
胰腺癌
肿瘤免疫
MAPK/ERK
JUN
RAS
发表日期：2026
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Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.

表观遗传分析可识别内分泌耐药性标志物，并为转移性去势抵抗性前列腺癌提供治疗选择

期刊:Cell Reports Medicine
影响因子:10.6
doi:10.1016/j.xcrm.2025.102215
Severson Tesa M, Minnee Emma, Zhu Yanyun, Schuurman Karianne, Nguyen Holly M, Brown Lisha G, Hakkola Sini, Menezes Renee, Gregoricchio Sebastian, Kim Yongsoo, Kneppers Jeroen, Linder Simon, Stelloo Suzan, Lieftink Cor, van der Heijden Michiel S, Nykter Matti, van der Noort Vincent, Sanders Joyce, Morris Ben, Jenster Guido, van Leenders Geert Jlh, Pomerantz Mark, Freedman Matthew L, Beijersbergen Roderick L, Urbanucci Alfonso, Wessels Lodewyk, Nelson Peter S, Corey Eva, Prekovic Stefan, Zwart Wilbert, Bergman Andries M
免疫/内分泌
表观遗传
肿瘤免疫
发表日期：2025
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CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma

CRISPR筛选发现ATPase VCP是胆管癌中一个可药物靶向的治疗弱点

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2519568122
Yang, Wu; Wang, Siying; Ji, Shuyi; Wang, Jian; Lian, Shuo; Li, Zhe; Jansen, Robin A; Wu, Wei; Niu, Kongyan; Sun, Zhen; Jia, Qi; Zheng, Jiaojiao; Zhu, Huijue; Deng, Xuan; Wang, Liqin; Fan, Zhoulong; Shi, Yaoping; Lieftink, Cor; Guan, Ming; Beijersbergen, Roderick L; Qin, Wenxin; Gao, Qiang; Bernards, René; Jin, Haojie
VCP
肿瘤
胆管癌
肿瘤免疫
发表日期：2025
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An antibiotic that mediates immune destruction of senescent cancer cells.

一种能介导免疫系统破坏衰老癌细胞的抗生素

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2417724121
Casagrande Raffi Gabriele, Chen Jian, Feng Xuezhao, Chen Zhen, Lieftink Cor, Deng Shuang, Mo Jinzhe, Zeng Chuting, Steur Marit, Wang Jing, Bleijerveld Onno B, Hoekman Liesbeth, van der Wel Nicole, Wang Feng, Beijersbergen Roderick, Zheng Jian, Bernards Rene, Wang Liqin
细胞生物学
肿瘤免疫
发表日期：2024
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Mammalian life depends on two distinct pathways of DNA damage tolerance

哺乳动物的生命依赖于两种不同的DNA损伤耐受途径。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2216055120
Buoninfante, Olimpia Alessandra; Pilzecker, Bas; Spanjaard, Aldo; de Groot, Daniël; Prekovic, Stefan; Song, Ji-Ying; Lieftink, Cor; Ayidah, Matilda; Pritchard, Colin E J; Vivié, Judith; Mcgrath, Kathleen E; Huijbers, Ivo J; Philipsen, Sjaak; von Lindern, Marieke; Zwart, Wilbert; Beijersbergen, Roderick L; Palis, James; van den Berk, Paul C M; Jacobs, Heinz
毒理研究
发表日期：2023
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A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator

一项针对人类前列腺癌细胞的全基因组 CRISPR 筛选揭示了巨噬细胞介导的细胞杀伤的驱动因素，并将 AR 定位为肿瘤内在的免疫调节因子。

期刊:
影响因子:
doi:10.1101/2023.06.06.543873
Zaalberg, Anniek; Minnee, Emma; Mayayo-Peralta, Isabel; Schuurman, Karianne; Gregoricchio, Sebastian; van Schaik, Thijs A; Hoekman, Liesbeth; Li, Dapei; Corey, Eva; Janssen, Hans; Lieftink, Cor; Prekovic, Stefan; Altelaar, Maarten; Nelson, Peter S; Beijersbergen, Roderick L; Zwart, Wilbert; Bergman, Andries
细胞生物学
肿瘤
巨噬细胞
前列腺癌
免疫/内分泌
肿瘤免疫
巨噬细胞
发表日期：2023
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Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients

增强子谱分析可识别内分泌耐药的表观遗传标记，并揭示转移性去势抵抗性前列腺癌患者的治疗选择。

期刊:
影响因子:
doi:10.1101/2023.02.24.23286403
Severson, Tesa M; Zhu, Yanyun; Prekovic, Stefan; Schuurman, Karianne; Nguyen, Holly M; Brown, Lisha G; Hakkola, Sini; Kim, Yongsoo; Kneppers, Jeroen; Linder, Simon; Stelloo, Suzan; Lieftink, Cor; van der Heijden, Michiel; Nykter, Matti; van der Noort, Vincent; Sanders, Joyce; Morris, Ben; Jenster, Guido; van Leenders, Geert Jlh; Pomerantz, Mark; Freedman, Matthew L; Beijersbergen, Roderick L; Urbanucci, Alfonso; Wessels, Lodewyk; Corey, Eva; Zwart, Wilbert; Bergman, Andries M
表观遗传
前列腺癌
肿瘤免疫
肿瘤
发表日期：2023
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Correction to: A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

更正：未折叠蛋白反应应激传感器ERN1在调节KRAS突变结肠癌对MEK抑制剂的反应中的作用

期刊:Genome Medicine
影响因子:11.2
doi:10.1186/s13073-020-00815-5
Šuštić, Tonći; van Wageningen, Sake; Bosdriesz, Evert; Reid, Robert J D; Dittmar, John; Lieftink, Cor; Beijersbergen, Roderick L; Wessels, Lodewyk F A; Rothstein, Rodney; Bernards, René
肿瘤
肠癌
肿瘤免疫
ERN1
RAS
发表日期：2021
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It takes two to tango, and the right music: Synergistic drug combinations with cell-cycle phase-dependent sensitivities

跳探戈需要两个人，还需要合适的音乐：具有细胞周期阶段依赖性敏感性的协同药物组合

期刊:EBioMedicine
影响因子:10.8
doi:10.1016/j.ebiom.2021.103448
Lieftink, Cor; Beijersbergen, Roderick L
细胞生物学
发表日期：2021
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A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma

CRISPR筛选发现CDK7是肝细胞癌的治疗靶点

期刊:Cell Research
影响因子:25.9
doi:10.1038/s41422-018-0020-z
Wang, Cun; Jin, Haojie; Gao, Dongmei; Wang, Liqin; Evers, Bastiaan; Xue, Zheng; Jin, Guangzhi; Lieftink, Cor; Beijersbergen, Roderick L; Qin, Wenxin; Bernards, René
肿瘤免疫
CDK7
细胞生物学
肿瘤
发表日期：2018
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