Liggett Stephen B相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Accelerating GPCR drug discovery through computation and experiment integrated with direct detection of ligand binding events

通过计算和实验相结合，并直接检测配体结合事件，加速GPCR药物发现。

doi:10.1038/s44386-026-00046-5

Su, Judith; Liggett, Stephen B; Kim, Soo-Kyung; Kim, Donghwa; Goddard, William A 3rd

GPCR/Calcium/cAMP

发表日期：2026

文献求助收藏

TAS2R5 screening reveals biased agonism that fails to evoke internalization and downregulation resulting in attenuated desensitization.

TAS2R5 筛选揭示了偏向性激动作用，未能引起内化和下调，导致脱敏作用减弱

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0315820

Kim Donghwa, Strzelinski Hannah R, Liggett Stephen B

发表日期：2025

文献求助收藏

β(1)- and β(2)-adrenergic Receptor Haplotypes Regulate Therapeutic Responses to Placebo and the Biased Ligand β-blocker Bucindolol

β(1)-和β(2)-肾上腺素能受体单倍型调节安慰剂和偏向性配体β受体阻滞剂布新洛尔的治疗反应

doi:10.1101/2025.08.22.25333921

Carroll, Ian A; Slavov, Dobromir; Jonas, Eric R; Minobe, Wayne A; Walker, Lori A; Ambardekar, Amrut V; McKinsey, Timothy A; Knaupp, Ammon D; Kim, Donghwa; Liggett, Stephen B; Bristow, Michael R

免疫/内分泌

发表日期：2025

文献求助收藏

Agonist activation to open the Gα subunit of the GPCR-G protein precoupled complex defines functional agonist activation of TAS2R5

激动剂激活以打开 GPCR-G 蛋白预偶联复合物的 Gα 亚基，这定义了 TAS2R5 的功能性激动剂激活。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2409987121

Young Yang, Moon; Duy Mac, Khuong; Strzelinski, Hannah R; Hoffman, Samantha A; Kim, Donghwa; Kim, Soo-Kyung; Su, Judith; Liggett, Stephen B; Goddard, William A 3rd

GPCR/Calcium/cAMP

发表日期：2024

文献求助收藏

How carvedilol does not activate β(2)-adrenoceptors

卡维地洛如何不激活β(2)-肾上腺素受体

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-023-42848-5

Lefkowitz, Robert J; Rockman, Howard A; Shim, Paul J; Liu, Samuel; Ahn, Seungkirl; Pani, Biswaranjan; Rajagopal, Sudarshan; Shenoy, Sudha K; Bouvier, Michel; Benovic, Jeffrey L; Liggett, Stephen B; Ruffolo, Robert R; Bristow, Michael R; Packer, Milton

免疫/内分泌

发表日期：2023

文献求助收藏

An extensive β1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies

广泛的β1-肾上腺素能受体基因信号网络调控扩张型心肌病中的分子重塑

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.169720

Tatman, Philip D; Kao, David P; Chatfield, Kathryn C; Carroll, Ian A; Wagner, Jessica A; Jonas, Eric R; Sucharov, Carmen C; Port, J David; Lowes, Brian D; Minobe, Wayne A; Huebler, Sophia P; Karimpour-Fard, Anis; Rodriguez, Erin M; Liggett, Stephen B; Bristow, Michael R

免疫/内分泌

发表日期：2023

文献求助收藏

A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14

Par3/LIM激酶/Cofilin通路通过TAS2R14介导人类呼吸道平滑肌舒张

期刊:American Journal of Respiratory Cell and Molecular Biology

影响因子:5.3

doi:10.1165/rcmb.2022-0303OC

Woo, Jung-A A; Castaño, Maria; Kee, Teresa R; Lee, Jordan; Koziol-White, Cynthia J; An, Steven S; Kim, Donghwa; Kang, David E; Liggett, Stephen B

发表日期：2023

文献求助收藏

Author Correction: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics

作者更正：活化的cofilin通过损害tau介导的微管动力学加剧tau病理。

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-023-05644-x

Woo, Jung-A A; Liu, Tian; Fang, Cenxiao C; Cazzaro, Sara; Kee, Teresa; LePochat, Patrick; Yrigoin, Ksenia; Penn, Courtney; Zhao, Xingyu; Wang, Xinming; Liggett, Stephen B; Kang, David E

发表日期：2023

文献求助收藏

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators

利用频率锁定光学微谐振器，对浓度为泽普摩尔级的膜结合事件进行无标记实时监测

doi:10.1101/2023.09.20.558657

Gin, Adley; Nguyen, Phuong-Diem; Melzer, Jeffrey E; Li, Cheng; Strzelinski, Hannah; Liggett, Stephen B; Su, Judith

发表日期：2023

文献求助收藏

Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma

RGS2启动子基因变异在重症哮喘中的临床和分子意义

期刊:Journal of Allergy and Clinical Immunology

影响因子:11.2

doi:10.1016/j.jaci.2022.03.024

Cardet, Juan Carlos; Kim, Donghwa; Bleecker, Eugene R; Casale, Thomas B; Israel, Elliot; Mauger, David; Meyers, Deborah A; Ampleford, Elizabeth; Hawkins, Gregory A; Tu, Yaping; Liggett, Stephen B; Ortega, Victor E

发表日期：2022

文献求助收藏