日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elucidating brain transport pathways and cell type-dependent gene silencing of a durable lipid-siRNA conjugate administered into cerebrospinal fluid.

阐明脑脊液中注入的持久性脂质-siRNA缀合物的脑运输途径和细胞类型依赖性基因沉默

Sorets Alexander G, Schwensen Katrina R, Francini Nora, Kjar Andrew, Abdulrahman Adam M, Shostak Alena, Katdare Ketaki A, Schoch Kathleen M, Cowell Rebecca P, Park Joshua C, Ligocki Alexander P, Ford William T, Ventura-Antunes Lissa, Hoogenboezem Ella N, Prusky Alex, Castleberry Mark, Michell Danielle L, Fritsch Emma, Lyons Sarah M, Miller Timothy M, Vickers Kasey C, Schrag Matthew S, Duvall Craig L, Lippmann Ethan S

Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells.

基质硬度和剪切应力共同调节培养的人脑微血管内皮细胞的炎症表型

Yates Alexis K, Murray Heather, Kjar Andrew, Chavarria Daniel, Masters Haley, Kim Hyosung, Ligocki Alexander P, Jefferson Angela L, Lippmann Ethan S

Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid

评估衰老对递送至脑脊液中的脂质-siRNA缀合物的生物分布和基因沉默活性的影响

Ligocki, Alexander P; Sorets, Alexander G; Abdulrahman, Adam M; Francini, Nora; Park, Joshua C; Lee, Ju Ha; Ford, William T; Lyons, Sarah M; Fritsch, Emma L; Lamantia, Zachary E; Christov, Plamen P; Duvall, Craig L; Lippmann, Ethan S

Amyloid-β-regulated gene circuits for programmable Alzheimer's disease therapy.

淀粉样蛋白β调控基因回路用于可编程的阿尔茨海默病治疗

Spetz Madeline R, Kim Hyosung, Chavarria Daniel, Conger Dylan J, Shattuck-Brandt Rebecca, Shekharan Swathi R, Shostak Alena, Ligocki Alexander P, Brien Hannah J, Embalabala Rebecca J, Mobley Bret C, Schrag Matthew S, Lippmann Ethan S, Brunger Jonathan M

Cerebrospinal fluid flow extends to peripheral nerves further unifying the nervous system

脑脊液流动延伸至周围神经,进一步统一了神经系统。

Ligocki, Alexander P; Vinson, Augustine V; Yachnis, Anthony T; Dunn, William A Jr; Smith, Douglas E; Scott, Elizabeth A; Alvarez-Castanon, Jimena V; Baez Montalvo, Daniel E; Frisone, Olivia G; Brown, Gary A J; Pessa, Joel E; Scott, Edward W