日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

核磷蛋白支持WNT信号通路驱动的过度增殖和肿瘤起始

Kanellos, Georgios; Giacomelli, Chiara; Raven, Alexander; Vlahov, Nikola; Jin, Hu; Herviou, Pauline; Malla, Sudhir B; Nasreddin, Nadia; Centeno, Patricia P; Alexandrou, Constantinos; Gilroy, Kathryn; Baird, Rachel L; Pennel, Kathryn; Munro, June; Waldron, Joseph A; Hall, Holly; Officer-Jones, Leah; Bryson, Sheila; Strathdee, Douglas; Lilla, Sergio; Zanivan, Sara; Morrison, Vivienne; Nixon, Colin; Ridgway, Rachel A; Miller, Crispin; Knight, John R P; Campbell, Andrew D; Dunne, Philip D; Le Quesne, John; Edwards, Joanne; Park, Peter J; Bushell, Martin; Sansom, Owen J

CBL ubiquitin ligase targets translation as a degrader E3

CBL泛素连接酶作为降解酶E3靶向翻译。

Wicks, Alice T; Buetow, Lori; Suzuki, Toshiyasu; Schmidt, Tobias; Lilla, Sergio; Macmillan-Jones, Abigail; Turney, Jennifer; Gohlke, Andrea; Bushell, Martin; Hock, Andreas K; Huang, Danny T

Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a

巨噬细胞在向补体C5a迁移的过程中,能够自我生成并完善趋化梯度。

Kiran, Abhimanyu; Thomason, Peter A; Versluis, David M; Paschke, Peggy I; Donnelly, Hannah; Tweedy, Luke; Lilla, Sergio; Bravo-Ferrer, Isabel; Shergold, Amy; Devlin, Ryan; Roberts, Edward W; Insall, Robert H

Structural and functional analysis of the TGF-β mimic, TGM-2: an immunomodulatory helminth protein

TGF-β 模拟物 TGM-2 的结构和功能分析:一种免疫调节蠕虫蛋白

Ntang, Emmaculate Yaah; Cunningham, Kyle T; Singh, Shashi P; Ciancia, Claire; Sanders, Anna; Lilla, Sergio; Mukundan, Ananya; Ghogomu, Stephen M; Hinck, Andrew P; Maizels, Rick M

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer.

癌症中线粒体核糖体RNA基因的功能优势热点突变。

Boscenco Sonia, Tait-Mulder Jacqueline, Kim Minsoo, Tang Cerise, Park Tricia, McNulty Flora, Lilla Sergio, Zanivan Sara, Huerta-Uribe Alejandro, Nalbant Benan, Zucker Mark, Sumpton David, Monteuuis Geoffray, Jackson Christopher B, Wei Wei, Chinnery Patrick F, Chaligne Ronan, Lareau Caleb A, Reznik Ed, Gammage Payam A

Engineered Immunomodulatory Extracellular Vesicles from Epithelial Cells with the Capacity for Stimulation of Innate and Adaptive Immunity in Cancer and Autoimmunity

上皮细胞来源的工程化免疫调节细胞外囊泡具有刺激癌症和自身免疫中先天性和适应性免疫的能力

Luo, Xin; Kugeratski, Fernanda G; Dowlatshahi, Dara P; Sugimoto, Hikaru; Arian, Kent A; Fan, Yibo; Huang, Li; Wills, Danielle; Lilla, Sergio; Hodge, Kelly; Zanivan, Sara R; LeBleu, Valerie S; McAndrews, Kathleen M; Kalluri, Raghu

Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.

将 CBL TKBD 锁定在其天然构象中,为突变型 CBL 依赖性白血病提供了一种新的治疗机会

Ahmed Syed Feroj, Anand Jayanthi, Zhang Wei, Buetow Lori, Rishi Loveena, Mitchell Louise, Bohlen Jonathan, Lilla Sergio, Sibbet Gary J, Nixon Colin, Patel Amrita, Majorek Karolina A, Zanivan Sara, Bustamante Jacinta C, Sidhu Sachdev S, Blyth Karen, Huang Danny T

SICyLIA-cTMT dissects redox proteome dynamics with high accuracy and depth at microgram scale

SICyLIA-cTMT能够以微克级精度和深度解析氧化还原蛋白质组的动态变化。

Lilla, Sergio; Atkinson, Samuel; Radau, Sonja; Bailey, Ulla-Maja; Deshmukh, Atul Shahaji; van der Reest, Jiska; Kirkpatrick, Joanna; MacVicar, Thomas; Zanivan, Sara

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge.

CYRI-B 的缺失会促进成熟粘着斑的增大,并限制微管和 ERC1 进入细胞前缘。

Whitelaw Jamie A, Ghosh Sayantika, Lilla Sergio, Nikolaou Savvas, Tweedy Luke, Fort Loic, Paul Nikki R, Zanivan Sara, Gadegaard Nikolaj, Insall Robert H, Machesky Laura M

Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity

源自上皮细胞的工程化免疫调节细胞外囊泡获得了在癌症和自身免疫中对T细胞进行正向和负向共刺激的能力

Kugeratski, Fernanda G; LeBleu, Valerie S; Dowlatshahi, Dara P; Sugimoto, Hikaru; Arian, Kent A; Fan, Yibo; Huang, Li; Wells, Danielle; Lilla, Sergio; Hodge, Kelly; Zanivan, Sara; McAndrews, Kathleen M; Kalluri, Raghu