日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease

人类ACE2转基因猪易感SARS-CoV-2病毒,并会发展出类似COVID-19的疾病。

Long Fung Chau #,Simon Lillico #,Tanja Opriessnig,Rosemary Blake,Luc Tardy,Chen-Hsuin Lee,Scott Maxwell,Claire Warren,Elizabeth Thornton,Catherine L Mclaughlin,Gerry McLachlan,Christine Tait-Burkard,Sarah Fletcher,Stephen Anderson,Sharon Brown,Louise Gibbard,Thomas Tzelos,Dawn MacMillan-Christensen,J Kenneth Baillie,David A Dorward,David J Griffiths,Finn Grey

AAV-delivered PPT1 provides long-term neurological benefits in CLN1 mice and achieves therapeutic levels in sheep brain

AAV递送的PPT1在CLN1小鼠中可提供长期的神经系统获益,并在绵羊脑中达到治疗水平。

Alam, Md Suhail; Khatiwada, Apeksha; Eaton, Samantha L; Cohen, Daniel M; White, John; Derby, Melissa; Peterson, Drew; Rivera-Pena, Graciela; Nayal, Mohamad; Becker, Mallory; Beck, Heena; Li, Charlie; Gentzel, Renee; Atkins, George; Greenhalgh, Stephen N; Lillico, Simon G; Gregson, Rachael; Clutton, Eddie; Murdoch, Fraser; Nixon, James; Gray, Mark; Thompson, Gerard; McBride, Jodi; Wishart, Thomas M; Biferi, Maria Grazia; Ramsburg, Elizabeth

Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition

母体α-酪蛋白缺乏可延长后代的寿命并影响其身体组成。

Andreas F Kolb ,Claus Mayer ,Alina Zitskaja ,Linda Petrie ,Khulod Hasaballah ,Claire Warren ,Ailsa Carlisle ,Simon Lillico ,Bruce Whitelaw

New developments in biotechnology applied to animals: An assessment of the adequacy and sufficiency of current EFSA guidance for animal risk assessment

应用于动物的生物技术新进展:对欧洲食品安全局(EFSA)当前动物风险评估指南的充分性和有效性的评估

Casacuberta, Josep; Barro, Francisco; Braeuning, Albert; de Maagd, Ruud; Epstein, Michelle M; Frenzel, Thomas; Gallois, Jean-Luc; Koning, Frits; Messéan, Antoine; Moreno, F Javier; Nogué, Fabien; Schulman, Alan H; Tebbe, Christoph; Veromann, Eve; Firbank, Leslie; Glandorf, Debora; Herskin, Mette S; Lillico, Simon Geoffrey; Ornsrud, Robin; Troedsson-Wargelius, Anna; Ardizzone, Michele; Lenzi, Paolo; M Camargo, Ana; Papadopoulou, Nikoletta; Schoonjans, Reinhilde; Vitali, Marika; Savoini, Giovanni

Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen

基于全基因组 CRISPR 敲除筛选验证牛疱疹病毒 1 型候选宿主细胞进入因子

Wenfang Spring Tan,Enguang Rong,Inga Dry,Simon Lillico,Andy Law,Paul Digard,Bruce Whitelaw,Robert G Dalziel

GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen

全基因组 CRISPR 敲除筛选结果表明,GARP 和 EARP 是 BoHV-1 有效复制所必需的。

Tan, Wenfang S; Rong, Enguang; Dry, Inga; Lillico, Simon G; Law, Andy; Digard, Paul; Whitelaw, Bruce; Dalziel, Robert G

Generation of sheep with defined FecB(B) and TBXT mutations and porcine blastocysts with KCNJ5(G151R/+) mutation using prime editing

利用先导编辑技术生成携带特定 FecB(B) 和 TBXT 突变的绵羊以及携带 KCNJ5(G151R/+) 突变的猪胚泡。

Zhou, Shiwei; Lenk, Laura Johanna; Gao, Yawei; Wang, Yuhui; Zhao, Xiaoe; Pan, Menghao; Huang, Shuhong; Sun, Kexin; Kalds, Peter; Luo, Qi; Lillico, Simon; Sonstegard, Tad; Scholl, Ute I; Ma, Baohua; Petersen, Bjoern; Chen, Yulin; Wang, Xiaolong

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep

酶替代疗法治疗小鼠和绵羊CLN1疾病的跨物种疗效

Nelvagal, Hemanth R; Eaton, Samantha L; Wang, Sophie H; Eultgen, Elizabeth M; Takahashi, Keigo; Le, Steven Q; Nesbitt, Rachel; Dearborn, Joshua T; Siano, Nicholas; Puhl, Ana C; Dickson, Patricia I; Thompson, Gerard; Murdoch, Fraser; Brennan, Paul M; Gray, Mark; Greenhalgh, Stephen N; Tennant, Peter; Gregson, Rachael; Clutton, Eddie; Nixon, James; Proudfoot, Chris; Guido, Stefano; Lillico, Simon G; Whitelaw, C Bruce A; Lu, Jui-Yun; Hofmann, Sandra L; Ekins, Sean; Sands, Mark S; Wishart, Thomas M; Cooper, Jonathan D

Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment

大型动物神经系统疾病建模:模型选择和临床评估标准

Eaton, Samantha L; Murdoch, Fraser; Rzechorzek, Nina M; Thompson, Gerard; Hartley, Claudia; Blacklock, Benjamin Thomas; Proudfoot, Chris; Lillico, Simon G; Tennant, Peter; Ritchie, Adrian; Nixon, James; Brennan, Paul M; Guido, Stefano; Mitchell, Nadia L; Palmer, David N; Whitelaw, C Bruce A; Cooper, Jonathan D; Wishart, Thomas M

Regulatory frameworks can facilitate or hinder the potential for genome editing to contribute to sustainable agricultural development

监管框架既可以促进基因组编辑技术对可持续农业发展的潜在贡献,也可以阻碍其发挥促进作用。

Mbaya, Hellen; Lillico, Simon; Kemp, Steve; Simm, Geoff; Raybould, Alan