Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa.

大环内酯类药物可增加人鼻窦上皮细胞中 11β-羟基类固醇脱氢酶 1 的表达，从而促进鼻窦黏膜中糖皮质激素的激活