日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells

生物正交束缚增强活细胞中药物片段对 G 蛋白偶联受体的亲和力

Jordan M Mattheisen, Chris Limberakis, Roger B Ruggeri, Matthew S Dowling, Christopher W Am Ende, Emilie Ceraudo, Thomas Huber, Christopher L McClendon, Thomas P Sakmar

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

人胰高血糖素样肽-1受体的小分子口服激动剂

Griffith, David A; Edmonds, David J; Fortin, Jean-Philippe; Kalgutkar, Amit S; Kuzmiski, J Brent; Loria, Paula M; Saxena, Aditi R; Bagley, Scott W; Buckeridge, Clare; Curto, John M; Derksen, David R; Dias, João M; Griffor, Matthew C; Han, Seungil; Jackson, V Margaret; Landis, Margaret S; Lettiere, Daniel; Limberakis, Chris; Liu, Yuhang; Mathiowetz, Alan M; Patel, Jayesh C; Piotrowski, David W; Price, David A; Ruggeri, Roger B; Tess, David A

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules

非经典尺寸依赖性渗透作用定义了大分子药物被动吸附的界限

Pye, Cameron R; Hewitt, William M; Schwochert, Joshua; Haddad, Terra D; Townsend, Chad E; Etienne, Lyns; Lao, Yongtong; Limberakis, Chris; Furukawa, Akihiro; Mathiowetz, Alan M; Price, David A; Liras, Spiros; Lokey, R Scott

Evaluation of Cu-64 and Ga-68 Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β cell Imaging

评估 Cu-64 和 Ga-68 放射性标记的胰高血糖素样肽-1 受体激动剂作为胰腺 β 细胞成像的 PET 示踪剂

Bandara, Nilantha; Zheleznyak, Alex; Cherukuri, Kaavya; Griffith, David A; Limberakis, Chris; Tess, David A; Jianqing, Chen; Waterhouse, Rikki; Lapi, Suzanne E

Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes

降低代谢酮体还原率,发现用于治疗糖尿病的临床乙酰辅酶 A 羧化酶抑制剂

David A Griffith, Daniel W Kung, William P Esler, Paul A Amor, Scott W Bagley, Carine Beysen, Santos Carvajal-Gonzalez, Shawn D Doran, Chris Limberakis, Alan M Mathiowetz, Kirk McPherson, David A Price, Eric Ravussin, Gabriele E Sonnenberg, James A Southers, Laurel J Sweet, Scott M Turner, Felix F V

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance()

优化环肽的药代动力学性质:侧链取代对渗透性和清除率的影响()

Rand, Arthur C; Leung, Siegfried S F; Eng, Heather; Rotter, Charles J; Sharma, Raman; Kalgutkar, Amit S; Zhang, Yizhong; Varma, Manthena V; Farley, Kathleen A; Khunte, Bhagyashree; Limberakis, Chris; Price, David A; Liras, Spiros; Mathiowetz, Alan M; Jacobson, Matthew P; Lokey, R Scott

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

一类源自蛋白激酶抑制剂药效团的选择性抗菌药

J Richard Miller, Steve Dunham, Igor Mochalkin, Craig Banotai, Matthew Bowman, Susan Buist, Bill Dunkle, Debra Hanna, H James Harwood, Michael D Huband, Alla Karnovsky, Michael Kuhn, Chris Limberakis, Jia Y Liu, Shawn Mehrens, W Thomas Mueller, Lakshmi Narasimhan, Adam Ogden, Jeff Ohren, J V N Vara