日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

An aminosterol breaks the autocatalytic cycle of Aβ(42) aggregation and protects cell membranes from its soluble aggregates

氨基甾醇可破坏Aβ(42)聚集的自催化循环，并保护细胞膜免受其可溶性聚集体的侵害。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2417944122
Fallot, Lucas B; Pinc, Johnathan R; Buselmeier, Joseph E; Palchak, Julia C; Shroff, Supria S; Zang, Kaitlyn; Rinauro, Dillon J; Bacon, Kate M; Nguyen, Michael; Schleck, Mary Claire; Cornell, Alyssa R; Oshidar, Alexandra; Darrell, Donald J; Gabriel, Justus M; Wright, Aidan K; Sasser, Liam R; Kreiser, Ryan P; Burpo, F John; Santambrogio, Alessia; Xu, Peifeng; Kubiak, Robert W 2nd; Loverde, Joseph; Jaffett, Victor A; Toole, Justin R; Barbut, Denise; Zasloff, Michael; Chiti, Fabrizio; Dear, Alexander J; Vendruscolo, Michele; Limbocker, Ryan
细胞生物学
发表日期：2025
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Polyphenol-Mediated Peptide Assembly Modulates Melittin Toxicity: A Structure-Activity Strategy for Neutralizing the Interface Affinity of Pore-Forming Toxins to Cell Membranes

多酚介导的肽组装调节蜂毒肽的毒性：一种中和成孔毒素与细胞膜界面亲和力的构效关系策略

期刊:ACS Applied Materials & Interfaces
影响因子:8.2
doi:10.1021/acsami.5c09472
Han, Hojin; Palchak, Julia C; Pinc, Johnathan R; Nguyen, Michael; Atchley, Keira A; Darrell, Donald J; Kim, Elaine S; Lee, Patrick H; Schleck, Mary Claire; Cornell, Alyssa R; Buselmeier, Joseph E; Bacon, Kate M; Zang, Kaitlyn; Burpeau, Nathan; Gabriel, Justus M; Anderson, Carol A; Burpo, F John; Fallot, Lucas B; Yuk, Simuck F; Limbocker, Ryan
细胞生物学
毒理研究
发表日期：2025
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From Pathology to Materials Science and Engineering: Harnessing the Amyloid State for Biotechnological Applications

从病理学到材料科学与工程：利用淀粉样蛋白状态进行生物技术应用

期刊:ACS Applied Materials & Interfaces
影响因子:8.2
doi:10.1021/acsami.5c11847
Fallot, Lucas B; Natarajan, Chandramouli; Anderson, Carol A; Nagelli, Enoch A; Burpo, F John; Limbocker, Ryan
发表日期：2025
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Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

错误折叠蛋白寡聚体：形成机制、细胞毒性作用及针对蛋白错误折叠疾病的药理学方法

期刊:Molecular Neurodegeneration
影响因子:17.5
doi:10.1186/s13024-023-00651-2
Rinauro, Dillon J; Chiti, Fabrizio; Vendruscolo, Michele; Limbocker, Ryan
细胞生物学
毒理研究
发表日期：2024
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A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions

不同金属离子稳定的Aβ寡聚体的结构与神经毒性作用的关系

期刊:ACS Chemical Neuroscience
影响因子:4.1
doi:10.1021/acschemneuro.3c00718
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Michele Vendruscolo
神经
发表日期：2024
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Editorial: Promising therapeutic strategies for Alzheimer's disease: a focus on amyloid-β targeting

社论：阿尔茨海默病治疗的新策略：聚焦β-淀粉样蛋白靶向治疗

期刊:Frontiers in Neuroscience
影响因子:3.2
doi:10.3389/fnins.2024.1415641
Bigi, Alessandra; Limbocker, Ryan; Cecchi, Cristina
阿尔茨海默症
发表日期：2024
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Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases

对有毒和无毒错误折叠蛋白寡聚体对的表征阐明了蛋白质错误折叠疾病中寡聚体毒性的结构决定因素

期刊:Accounts of Chemical Research
影响因子:17.7
doi:10.1021/acs.accounts.3c00045
Limbocker, Ryan; Cremades, Nunilo; Cascella, Roberta; Tessier, Peter M; Vendruscolo, Michele; Chiti, Fabrizio
毒理研究
发表日期：2023
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Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes

氨基甾醇对蛋白质聚集体的保护作用与其化学结构和调节生物膜的能力的定量归因

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.3c00182
Silvia Errico, Giacomo Lucchesi, Davide Odino, Enass Youssef Osman, Roberta Cascella, Lorenzo Neri, Claudia Capitini, Martino Calamai, Francesco Bemporad, Cristina Cecchi, William A Kinney, Denise Barbut, Annalisa Relini, Claudio Canale, Gabriella Caminati, Ryan Limbocker, Michele Vendruscolo, Micha
微生物学
发表日期：2023
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Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation

维生素 A 和维生素 E 代谢物的组合可抵抗淀粉样β蛋白的聚集

期刊:ACS Chemical Neuroscience
影响因子:4.1
doi:10.1021/acschemneuro.2c00523
Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Michele Vendruscolo
代谢
发表日期：2023
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A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents

一种可透过血脑屏障的氨基甾醇通过调节细胞膜来减轻多种成孔剂的毒性

期刊:ACS Chemical Neuroscience
影响因子:3.9
doi:10.1021/acschemneuro.1c00840
Kreiser, Ryan P; Wright, Aidan K; Sasser, Liam R; Rinauro, Dillon J; Gabriel, Justus M; Hsu, Claire M; Hurtado, Jorge A; McKenzie, Tristan L; Errico, Silvia; Albright, J Alex; Richardson, Lance; Jaffett, Victor A; Riegner, Dawn E; Nguyen, Lam T; LeForte, Kathleen; Zasloff, Michael; Hollows, Jared E; Chiti, Fabrizio; Vendruscolo, Michele; Limbocker, Ryan
血脑屏障
细胞生物学
毒理研究
神经科学
发表日期：2022
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