Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies
Rasgrp1突变增加幼稚T细胞CD44表达,并驱动mTOR依赖性的Helios⁺ T细胞和自身抗体的积累。
期刊:Elife
影响因子:6.4
doi:10.7554/eLife.01020
Daley, Stephen R; Coakley, Kristen M; Hu, Daniel Y; Randall, Katrina L; Jenne, Craig N; Limnander, Andre; Myers, Darienne R; Polakos, Noelle K; Enders, Anselm; Roots, Carla; Balakishnan, Bhavani; Miosge, Lisa A; Sjollema, Geoff; Bertram, Edward M; Field, Matthew A; Shao, Yunli; Andrews, T Daniel; Whittle, Belinda; Barnes, S Whitney; Walker, John R; Cyster, Jason G; Goodnow, Christopher C; Roose, Jeroen P
mTOR
T细胞
CD44
T细胞
细胞生物学
CD4
免疫/内分泌