日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Profiling of SARS-CoV-2 virus shedding, antibody neutralization, and T-cell receptor repertoires in a large, multi-center cohort of young adults with varied prior exposures

对一组具有不同既往暴露史的年轻成年人进行SARS-CoV-2病毒脱落、抗体中和和T细胞受体库的大型多中心队列研究

Fiore-Gartland, Andrew; Mayer-Blackwell, Koshlan; Stray, James; Neradilek, Moni; Lo, April; Hannah, Alex; Dong, Tracy; Serebryannyy, Leonid; Carroll, Robin; Lin, Bob C; Koup, Richard A; Garcia, Nina Marie G; Marcelin, Jasmine R; Pettifor, Audrey E; Janes, Holly; Brown, Elizabeth R; Yen, Catherine; Andriesen, Jessica; Corey, Lawrence; Stephenson, Kathryn E; Kublin, James G

A Test-Negative Design for Immune Correlates Approximates a Traditional Exposure-Proximal Design but Requires Far Fewer Blood Samples

免疫相关性检测阴性设计与传统的暴露近端设计近似,但所需的血液样本量要少得多。

Follmann, Dean; Dang, Lauren; Chu, Eric; Fintzi, Jonathan; Janes, Holly; Gilbert, Peter B; Andrews, Leah I B; Serebryannyy, Leonid; Carroll, Robin; Lin, Bob; Koup, Richard; Toma, Jon; Deng, Weiping; Priddy, Frances; Dixit, Avika; Zhou, Honghong; Baden, Lindsey; El Sahly, Hana M

Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response.

抗原持续存在和 TLR 刺激有助于诱导持久的 HIV-1 特异性中和抗体反应

Matsuda Kenta, Harrison Mitra, Wettstein Eleanor, Pederson Jessica, Pullano Alyssa A, Bolkhovitinov Lyuba, Kim Breanna, Steinberg Isabel, Griesman Trevor, Stuccio Sarah, Rogan Daniel, Patamawenu Andy, Shofner Tulley, Wright Nathaniel E, Webber Jonathan D, Van't Veer Freya, Roenicke Rachel, Koory Emma, Roeder Peyton M, Ober Ellison, Leach Benjamin, Tsybovsky Yaroslav, Stephens Tyler, Del Moral-Sanchez Ivan, Bontjer Ilja, McGinnes-Cullen Lori W, Chu Eric, Liang Jason, Torres Jonathan L, Lin Ryan N, Tran Andy S, Dziubla Gabrielle, Serebryannyy Leonid, Narpala Sandeep, Lin Bob, Castro Mike, Ozorowski Gabriel, Ward Andrew B, Sanders Rogier W, Kwong Peter D, Guenaga Javier, Wyatt Richard, Morrison Trudy, Connors Mark

Safety and pharmacokinetics of N6LS, a broadly neutralising monoclonal antibody for HIV: a phase 1, open-label, dose-escalation study in healthy adults

N6LS(一种广谱中和HIV的单克隆抗体)的安全性和药代动力学:一项在健康成人中进行的1期开放标签剂量递增研究

Wu, Richard L; Houser, Katherine V; Gaudinski, Martin R; Widge, Alicia T; Awan, Seemal F; Carter, Cristina A; Holman, LaSonji A; Saunders, Jamie; Hendel, Cynthia S; Eshun, Aba; Whalen, William R; Wang, Xiaolin; Arthur, Anita; Cunningham, Jennifer E; Beck, Allison; Casazza, Joseph P; Yamshchikov, Galina V; Rothwell, Ro Shauna; Strom, Larisa; Dittakavi, Tejaswi; Happe, Myra; Hickman, Somia P; Conan-Cibotti, Michelle; Carlton, Kevin; Zhang, Lily; Huang, Yunda; Capparelli, Edmund V; Castro, Mike; Lin, Bob C; O'Connell, Sarah; Flach, Britta S; Bailer, Robert T; Narpala, Sandeep R; Serebryannyy, Leonid; McDermott, Adrian B; Arnold, Frank J; Gall, Jason G; Vazquez, Sandra; Berkowitz, Nina M; Gordon, Ingelise J; Chen, Grace L; Kwong, Peter D; Huang, Jinghe; Pierson, Theodore C; Connors, Mark; Mascola, John R; Zhou, Tongqing; Doria-Rose, Nicole A; Koup, Richard A; Dropulic, Lesia K

Prospective SARS-CoV-2 additional vaccination in immunosuppressant-treated individuals with autoimmune diseases in a randomized controlled trial

在一项随机对照试验中,对接受免疫抑制剂治疗的自身免疫性疾病患者进行SARS-CoV-2额外疫苗接种的预期效果

Mackay, Meggan; Wagner, Catriona A; Pinckney, Ashley; Cohen, Jeffrey A; Wallace, Zachary S; Khosroshahi, Arezou; Sparks, Jeffrey A; Lord, Sandra; Saxena, Amit; Caricchio, Roberto; Kim, Alfred Hj; Kamen, Diane L; Koumpouras, Fotios; Askanase, Anca D; Smith, Kenneth; Guthridge, Joel M; Pardo, Gabriel; Mao-Draayer, Yang; Macwana, Susan; McCarthy, Sean; Sherman, Matthew A; Daneshfar Hamrah, Sanaz; Veri, Maria; Walker, Sarah; York, Kate; Tedeschi, Sara K; Wang, Jennifer; Dziubla, Gabrielle E; Castro, Mike; Carroll, Robin; Narpala, Sandeep R; Lin, Bob C; Serebryannyy, Leonid; McDermott, Adrian B; Barry, William T; Goldmuntz, Ellen; McNamara, James; Payne, Aimee S; Bar-Or, Amit; Khanna, Dinesh; James, Judith A

Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth

酵母展示揭示了大量突变,这些突变可将融合肽疫苗诱导产生的抗体对 HIV-1 的中和广度提高到 59% 以上

França, Camila T; Pletnev, Sergei; Madan, Bharat; Katsamba, Phinikoula S; McKee, Krisha; Morano, Nicholas C; Zhang, Baoshan; Bahna, Fabiana; Bylund, Tatsiana; Lin, Bob C; Louder, Mark K; Mannepalli, Seetha; Nimrania, Rajani; O'Dell, Sijy; Doria-Rose, Nicole A; Kwong, Peter D; Shapiro, Lawrence; Sheng, Zizhang; Zhou, Tongqing; DeKosky, Brandon J

Rapid loss of activity but not serum concentration in a passive infusion clinical trial of an HIV neutralizing antibody

在HIV中和抗体的被动输注临床试验中,活性迅速丧失,但血清浓度未下降。

Mahomed, Sharana; Mkhize, Nonhlanhla N; Serebryannyy, Leonid A; Hermanus, Tandile; Kgagudi, Prudence; Kaldine, Haajira; Lambson, Bronwen; Narpala, Sandeep R; Basappa, Manjula; Castro, Mike; Lin, Bob C; Carlton, Kevin; Sands, Jason T; Gall, Jason G; Koup, Richard A; Morris, Lynn; Karim, Quarraisha Abdool; Moore, Penny L; Karim, Salim Abdool; Doria-Rose, Nicole

Virologic effects of broadly neutralizing antibodies VRC01LS and VRC07-523LS on chronic HIV-1 infection

广谱中和抗体VRC01LS和VRC07-523LS对慢性HIV-1感染的病毒学影响

Happe, Myra; Lynch, Rebecca M; Fichtenbaum, Carl J; Heath, Sonya L; Koletar, Susan L; Landovitz, Raphael J; Presti, Rachel M; Santana-Bagur, Jorge L; Tressler, Randall L; Holman, LaSonji A; Novik, Laura; Roa, Jhoanna C; Rothwell, Ro Shauna; Strom, Larisa; Wang, Jing; Hu, Zonghui; Conan-Cibotti, Michelle; Bhatnagar, Anjali M; Dwyer, Bridget; Ko, Sung Hee; Belinky, Frida; Namboodiri, Aryan M; Pandey, Janardan P; Carroll, Robin; Basappa, Manjula; Serebryannyy, Leonid; Narpala, Sandeep R; Lin, Bob C; McDermott, Adrian B; Boritz, Eli A; Capparelli, Edmund V; Coates, Emily E; Koup, Richard A; Ledgerwood, Julie E; Mascola, John R; Chen, Grace L; Tebas, Pablo

Hyaluronidase-enhanced subcutaneous delivery of bNAbs: a phase 1 randomized controlled clinical trial in HIV-uninfected women

透明质酸酶增强皮下递送广谱中和抗体:一项针对未感染 HIV 的女性的 1 期随机对照临床试验

Mahomed, Sharana; Osman, Farzana; Beliveau, Martin; Heredia-Ortiz, Roberto; Carlton, Kevin; Wang, Jennifer; Mughal, Madeeha; Low, Kwang; Narpala, Sandeep; Lin, Bob C; Castro, Mike; Serebryannyy, Leonid; Koup, Richard A; Karim, Quarraisha Abdool; Abdool Karim, Salim S

Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

在美国,一项首次人体试验(HVTN 136/HPTN 092)研究了抗HIV-1单克隆抗体PGT121.414.LS单独使用以及与VRC07-523LS联合使用时,在美国未感染HIV的成年人中的安全性、耐受性、药代动力学和中和活性。该研究为一项开放标签、随机对照的I期临床试验。

Edupuganti, Srilatha; Hurt, Christopher B; Stephenson, Kathryn E; Huang, Yunda; Paez, Carmen A; Yu, Chenchen; Yen, Catherine; Hanscom, Brett; He, Zonglin; Miner, Maurine D; Gamble, Theresa; Heptinstall, Jack; Seaton, Kelly E; Domin, Elizabeth; Lin, Bob C; McKee, Krisha; Doria-Rose, Nicole; Regenold, Stephanie; Spiegel, Hans; Anderson, Maija; McClosky, Nadia; Zhang, Lily; Piwowar-Manning, Estelle; Ackerman, Margaret E; Pensiero, Michael; Dye, Bonnie J; Landovitz, Raphael J; Mayer, Kenneth; Siegel, Marc; Sobieszczyk, Magdalena; Walsh, Stephen R; Gama, Lucio; Barouch, Dan H; Montefiori, David C; Tomaras, Georgia D