日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

PI3Kα抑制剂和降解剂Inavolisib可利用FGFR2增强PIK3CA突变实体瘤患者和临床前模型的疗效。

Juric Dejan, Song Kyung, Johnson Radia M, Accordino Melissa K, Bedard Philippe L, Cervantes Andrés, Gambardella Valentina, Hamilton Erika, Italiano Antoine, Kalinsky Kevin, Krop Ian E, Oliveira Mafalda, Saura Cristina, Schmid Peter, Turner Nicholas C, Varga Andreea, Gendreau Steven, Hwang Michael S, Kuang Zheng, Lau Jeffrey T, Lin Eva, Pham Trang, Maddalo Danilo, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Martin Scott, Sodir Nicole M, Sokol Ethan S, Whitfield Zachary J, Wong Alice, Yauch Robert L, Aimi Junko, Cheeti Sravanthi, Fredrickson Jill, Hilz Stephanie, Hafner Marc, Hutchinson Katherine E, Jin Yanling, Peters Ubong, Zingg Daniel, Royer-Joo Stephanie, Shankar Noopur, Schutzman Jennifer L, Jhaveri Komal L, Dey Anwesha

Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer.

配体激活的 EGFR/MAPK 信号通路(而非 PI3K)是结直肠癌中 EGFR 疗法产生耐药性的关键机制

Qu Xueping, Hamidi Habib, Johnson Radia M, Sokol Ethan S, Lin Eva, Eng Cathy, Kim Tae Won, Bendell Johanna, Sivakumar Smruthy, Kaplan Benjamin, de Sousa E Melo Felipe, Mancini Andrew, Wongchenko Matthew, Shi Yi, Shames David, Yan Yibing, Ciardiello Fortunato, Bais Carlos

Aryl Acid-Alcohol Cross-Coupling: C(sp(3))-C(sp(2)) Bond Formation from Nontraditional Precursors

芳基酸-醇交叉偶联:由非传统前体形成C(sp(3))-C(sp(2))键

Lin, Eva; Wang, Johnny Z; Mao, Edna; Tsang, Stephanie; Carsch, Kurtis M; Prieto Kullmer, Cesar N; McNamee, Ryan E; Long, Jeffrey R; Le, Chi Chip; MacMillan, David W C

Optimised Ribosome Profiling Reveals New Insights Into Translational Regulation in Synchronised Chlamydomonas reinhardtii Cultures

优化的核糖体谱分析揭示了同步化莱茵衣藻培养物中翻译调控的新见解

Yen-Ling Lin,Eva Yuhua Kuo,Shih-Yi Wang,Chih-Chi Lee,Su-Chiung Fang

KRAS Codon-Specific Mutations Differentially Toggle PI3K Pathway Signaling and Alter Sensitivity to Inavolisib (GDC-0077).

KRAS 密码子特异性突变差异性地切换 PI3K 通路信号传导并改变对 Inavolisib (GDC-0077) 的敏感性。

Song Kyung W, Ong Christy C, Lin Eva, Lau Jeff, Sodir Nicole M, Jin Dexter X, Hutchinson Katherine E, Xie Shiqi, Tan Jenille, Liang Yuxin, Modrusan Zora, Martin Scott E, Maddalo Danilo, Hafner Marc, Dey Anwesha

Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders

小分子抑制糖原合酶 1 用于治疗庞贝病和其他糖原累积症

Julie C Ullman, Kevin T Mellem, Yannan Xi, Vyas Ramanan, Hanne Merritt, Rebeca Choy, Tarunmeet Gujral, Lyndsay E A Young, Kerrigan Blake, Samnang Tep, Julian R Homburger, Adam O'Regan, Sandya Ganesh, Perryn Wong, Terrence F Satterfield, Baiwei Lin, Eva Situ, Cecile Yu, Bryan Espanol, Richa Sarwaikar

Concurrent Targeting of HDAC and PI3K to Overcome Phenotypic Heterogeneity of Castration-resistant and Neuroendocrine Prostate Cancers

同时靶向 HDAC 和 PI3K 以克服去势抵抗性和神经内分泌前列腺癌的表型异质性

Ailin Zhang #, Nathan A Lau #, Alicia Wong, Lisha G Brown, Ilsa M Coleman, Navonil De Sarkar, Dapei Li, Diana C DeLucia, Mark P Labrecque, Holly M Nguyen, Jennifer L Conner, Ruth F Dumpit, Lawrence D True, Daniel W Lin, Eva Corey, Joshi J Alumkal, Peter S Nelson, Colm Morrissey, John K Lee

Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors

变构型 AKT 抑制剂与 ATP 竞争型 AKT 抑制剂存在不同的耐药机制

Kristin M Zimmerman Savill, Brian B Lee #, Jason Oeh #, Jie Lin #, Eva Lin, Wei-Jen Chung, Amy Young, Wennie Chen, Monika Miś, Kathryn Mesh, Jeffrey Eastham, Florian Gnad, Zhaoshi Jiang, Eric W Stawiski, Benjamin Haley, Anneleen Daemen, Xiaojing Wang, Hartmut Koeppen, Zora Modrusan, Scott E Martin, 

PharmacoDB 2.0: improving scalability and transparency of in vitro pharmacogenomics analysis

PharmacoDB 2.0:提高体外药物基因组学分析的可扩展性和透明度

Feizi, Nikta; Nair, Sisira Kadambat; Smirnov, Petr; Beri, Gangesh; Eeles, Christopher; Esfahani, Parinaz Nasr; Nakano, Minoru; Tkachuk, Denis; Mammoliti, Anthony; Gorobets, Evgeniya; Mer, Arvind Singh; Lin, Eva; Yu, Yihong; Martin, Scott; Hafner, Marc; Haibe-Kains, Benjamin

Evaluation of statistical approaches for association testing in noisy drug screening data

对噪声药物筛选数据中关联性检验的统计方法进行评估

Smirnov, Petr; Smith, Ian; Safikhani, Zhaleh; Ba-Alawi, Wail; Khodakarami, Farnoosh; Lin, Eva; Yu, Yihong; Martin, Scott; Ortmann, Janosch; Aittokallio, Tero; Hafner, Marc; Haibe-Kains, Benjamin