日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Development of First-in-Class Cereblon-Recruiting RIPK1 Degraders

发现和开发首创的 Cereblon 募集 RIPK1 降解剂

Lu, Dong; Yu, Xin; Lin, Hanfeng; Cheng, Ran; Zhang, Min; Yang, Bin; Chen, Jingjing; Li, Feng; Qi, Xiaoli; Wang, Jin

Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders

对于高效PROTAC而言,亚化学计量降解并非必要:以不可逆共价BTK降解剂为例

Cheng, Ran; Lin, Hanfeng; Yu, Xin; Misra, Shrilekha; Mitchell, Andrew D; Woyach, Jennifer A; Qi, Xiaoli; Wang, Jin

COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale.

COOKIE-Pro:蛋白质组规模的共价抑制剂结合动力学分析。

Lin Hanfeng, Yang Bin, Ding Lang, Yang Yen-Yu, Holt Matthew V, Jung Sung Yun, Zhang Bing, Wang Meng C, Wang Jin

Design, Optimization, and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties

RIPK1降解剂的设计、优化和开发,以改善其药代动力学和药效学特性

Lu, Dong; Yu, Xin; Lin, Hanfeng; Cheng, Ran; Yang, Bin; Zhang, Min; Chen, Jingjing; Li, Feng; Qi, Xiaoli; Wang, Jin

Beyond the G-Loop: CRBN Molecular Glues Potently Target VAV1 via a Novel SH3 RT-Loop Degron

超越 G 环:CRBN 分子胶通过新型 SH3 RT 环降解子有效靶向 VAV1

Lin, Hanfeng; Yu, Xin; Haiyang; Cheng, Ran; Qi, Xiaoli; Yang, Yen-Yu; Zhou, Shengmin; Che, Xing; Wang, Jin

COOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale.

COOKIE-Pro:蛋白质组规模的共价抑制剂结合动力学分析

Lin Hanfeng, Yang Bin, Ding Lang, Yang Yen-Yu, Holt Matthew V, Jung Sung Yun, Zhang Bing, Wang Meng C, Wang Jin

Development of a Novel Amplifiable System to Quantify Hydrogen Peroxide in Living Cells

开发一种新型可放大系统以定量检测活细胞中的过氧化氢

Wang, Lingfei; Lin, Hanfeng; Yang, Bin; Jiang, Xiqian; Chen, Jianwei; Roy Chowdhury, Sandipan; Cheng, Ninghui; Nakata, Paul A; Lonard, David M; Wang, Meng C; Wang, Jin

Glutathione dynamics in subcellular compartments and implications for drug development

亚细胞区室中谷胱甘肽的动态变化及其对药物研发的影响

Lin, Hanfeng; Wang, Lingfei; Jiang, Xiqian; Wang, Jin

Lysineless HiBiT and NanoLuc Tagging Systems as Alternative Tools for Monitoring Targeted Protein Degradation

无赖氨酸HiBiT和NanoLuc标记系统作为监测靶向蛋白降解的替代工具

Lin, Hanfeng; Riching, Kristin; Lai, May Poh; Lu, Dong; Cheng, Ran; Qi, Xiaoli; Wang, Jin

Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement

开发用于研究RIPK1靶标结合的生化和细胞探针

Yu, Xin; Lin, Hanfeng; Li, Feng; Wang, Jin; Lu, Dong