日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation

GAT107 介导的 α7 烟碱乙酰胆碱受体信号通过降低 MnSOD-S-谷胱甘肽化来减轻巨噬细胞线粒体的氧化应激,从而减轻呼吸机相关性肺炎小鼠模型中的炎症性肺损伤和死亡率

Alex G Gauthier, Mosi Lin, Sidorela Zefi, Abhijit Kulkarni, Ganesh A Thakur, Charles R Ashby Jr, Lin L Mantell

A Standardized Botanical Composition Mitigated Acute Inflammatory Lung Injury and Reduced Mortality through Extracellular HMGB1 Reduction

标准化植物成分通过减少细胞外 HMGB1 减轻急性炎症性肺损伤并降低死亡率

Mesfin Yimam, Teresa Horm, Alexandria O'Neal, Ping Jiao, Mei Hong, Lidia Brownell, Qi Jia, Mosi Lin, Alex Gauthier, Jiaqi Wu, Kranti Venkat Mateti, Xiaojian Yang, Katelyn Dial, Sidorela Zefi, Lin L Mantell

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

2-O, 3-O 脱硫酸肝素 (ODSH) 通过恢复 HMGB1 受损的巨噬细胞功能来增加细菌清除率并减轻囊性纤维化中的肺损伤

Mao Wang, Alex G Gauthier, Thomas P Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R Ashby Jr, Lin L Mantell

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

GAT107 对 alpha7-烟碱胆碱能受体的正向变构调节通过降低巨噬细胞的氧化应激来增加高氧小鼠的细菌肺清除率

Alex G Gauthier, Jiaqi Wu, Mosi Lin, Ravikumar Sitapara, Abhijit Kulkarni, Ganesh A Thakur, Edward E Schmidt, Jeanette C Perron, Charles R Ashby Jr, Lin L Mantell

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

α7 烟碱乙酰胆碱受体激动剂 GTS-21 可通过减轻气道和循环系统中 HMGB1 的积聚来减轻高氧诱导的急性炎症性肺损伤

Ravikumar A Sitapara, Alex G Gauthier, Sergio I Valdés-Ferrer, Mosi Lin, Vivek Patel, Mao Wang, Ashley T Martino, Jeanette C Perron, Charles R Ashby Jr, Kevin J Tracey, Valentin A Pavlov, Lin L Mantell

The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

α7 烟碱乙酰胆碱受体激动剂 GTS-21 通过恢复高氧受损的巨噬细胞功能改善小鼠的细菌清除率

Ravikumar A Sitapara, Alex G Gauthier, Vivek S Patel, Mosi Lin, Michelle Zur, Charles R Ashby Jr, Lin L Mantell

The nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate/D-NO), increases survival by attenuating hyperoxia-compromised innate immunity in bacterial clearance in a mouse model of ventilator-associated pneumonia

一氧化氮供体 (Z)-1-[N-(2-氨基乙基)-N-(2-氨乙基)氨基]二氮-1-鎓-1,2-二醇 (DETA-NONOate/D-NO) 可通过减弱呼吸机相关性肺炎小鼠模型中因高氧受损的细菌清除先天免疫力来提高存活率

Ashwini Gore, Alex G Gauthier, Mosi Lin, Vivek Patel, Douglas D Thomas, Charles R Ashby Jr, Lin L Mantell

Dietary Antioxidants Significantly Attenuate Hyperoxia-Induced Acute Inflammatory Lung Injury by Enhancing Macrophage Function via Reducing the Accumulation of Airway HMGB1

膳食抗氧化剂通过减少气道 HMGB1 的积累增强巨噬细胞功能,显著减轻高氧诱导的急性炎症性肺损伤

Vivek Patel, Katelyn Dial, Jiaqi Wu, Alex G Gauthier, Wenjun Wu, Mosi Lin, Michael G Espey, Douglas D Thomas, Charles R Ashby Jr, Lin L Mantell

Nitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications

一氧化氮通过控制组蛋白翻译后修饰来调节癌症中的基因表达

Divya Vasudevan, Jason R Hickok, Rhea C Bovee, Vy Pham, Lin L Mantell, Neil Bahroos, Pinal Kanabar, Xing-Jun Cao, Mark Maienschein-Cline, Benjamin A Garcia, Douglas D Thomas

The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-κB-mediated release of high-mobility group box-1

依他尼酸可通过抑制 NF-κB 介导的高迁移率族蛋白 B1 释放来减轻高氧对巨噬细胞功能的损害

Mao Wang, Samir Gorasiya, Daniel J Antoine, Ravikumar A Sitapara, Wenjun Wu, Lokesh Sharma, Huan Yang, Charles R Ashby Jr, Divya Vasudevan, Michelle Zur, Douglas D Thomas, Lin L Mantell