USP25 directly interacts with and deubiquitinates PPARα to increase PPARα stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice.
USP25 直接与 PPARα 相互作用并使其去泛素化，从而增加肝细胞中 PPARα 的稳定性，并减轻高脂饮食诱导的小鼠 MASLD
期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-025-01444-4
Jin Leiming, Zhu Weiwei, Hu Xiang, Ye Lin, Lou Shuaijie, Zhang Qianhui, Wang Minxiu, Ye Bozhi, Min Julian, Wang Yi, Huang Lijiang, Luo Wu, Liang Guang
