日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Inhibition of Bromodomain Proteins Enhances Oncolytic HAdVC5 Replication and Efficacy in Pancreatic Ductal Adenocarcinoma (PDAC) Models.

抑制溴结构域蛋白可增强溶瘤HAdVC5在胰腺导管腺癌（PDAC）模型中的复制和疗效

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms25021265
Miao Tizong, Symonds Alistair, Hickman Oliver J, Wu Dongsheng, Wang Ping, Lemoine Nick, Wang Yaohe, Linardopoulos Spiros, Halldén Gunnel
肿瘤
肿瘤免疫
发表日期：2024
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CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells

CCT245718 是一种双重 FLT3/Aurora A 抑制剂，可克服急性髓系白血病细胞中由 D835Y 介导的 FLT3 抑制剂耐药性。

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-021-01527-2
Tariq, Muhammad Usama; Furqan, Muhammad; Parveen, Hira; Ullah, Rahim; Muddassar, Muhammad; Saleem, Rahman Shah Zaib; Bavetsias, Vassilios; Linardopoulos, Spiros; Faisal, Amir
白血病
细胞生物学
Aurora A
FLT3
发表日期：2021
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Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N(2)-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N(8)-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722)

引入甲基可抑制吡啶并[3,4-d]嘧啶单极纺锤体1 (MPS1) 抑制剂的代谢，并促成了 1 期临床候选药物 N(2)-(2-乙氧基-4-(4-甲基-4H-1,2,4-三唑-3-基)苯基)-6-甲基-N(8)-新戊基吡啶并[3,4-d]嘧啶-2,8-二胺 (BOS172722) 的发现。

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.8b00690
Woodward, Hannah L; Innocenti, Paolo; Cheung, Kwai-Ming J; Hayes, Angela; Roberts, Jennie; Henley, Alan T; Faisal, Amir; Mak, Grace Wing-Yan; Box, Gary; Westwood, Isaac M; Cronin, Nora; Carter, Michael; Valenti, Melanie; De Haven Brandon, Alexis; O'Fee, Lisa; Saville, Harry; Schmitt, Jessica; Burke, Rosemary; Broccatelli, Fabio; van Montfort, Rob L M; Raynaud, Florence I; Eccles, Suzanne A; Linardopoulos, Spiros; Blagg, Julian; Hoelder, Swen
代谢
发表日期：2018
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RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

RNAi 筛选揭示了细胞周期蛋白 G 相关激酶和 FBXW7 之间的合成致死性，这种致死性通过诱导异常有丝分裂而产生

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/bjc.2017.277
Dolly Saoirse O, Gurden Mark D, Drosopoulos Konstantinos, Clarke Paul, de Bono Johann, Kaye Stan, Workman Paul, Linardopoulos Spiros
细胞生物学
发表日期：2017
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Aurora Kinase Inhibitors: Current Status and Outlook

极光激酶抑制剂：现状与展望

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2015.00278
Bavetsias, Vassilios; Linardopoulos, Spiros
信号转导
发表日期：2015
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7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent

7-(吡唑-4-基)-3H-咪唑并[4,5-b]吡啶类衍生物用于激酶抑制：与Aurora-A的共结晶研究揭示了吡唑N1取代基取向的明显差异

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2015.08.003
Bavetsias, Vassilios; Pérez-Fuertes, Yolanda; McIntyre, Patrick J; Atrash, Butrus; Kosmopoulou, Magda; O'Fee, Lisa; Burke, Rosemary; Sun, Chongbo; Faisal, Amir; Bush, Katherine; Avery, Sian; Henley, Alan; Raynaud, Florence I; Linardopoulos, Spiros; Bayliss, Richard; Blagg, Julian
信号转导
发表日期：2015
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Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)

基于结构的口服生物利用度高的1H-吡咯并[3,2-c]吡啶类有丝分裂激酶单极纺锤体1 (MPS1) 抑制剂设计

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm401395s
Naud, Sébastien; Westwood, Isaac M; Faisal, Amir; Sheldrake, Peter; Bavetsias, Vassilios; Atrash, Butrus; Cheung, Kwai-Ming J; Liu, Manjuan; Hayes, Angela; Schmitt, Jessica; Wood, Amy; Choi, Vanessa; Boxall, Kathy; Mak, Grace; Gurden, Mark; Valenti, Melanie; de Haven Brandon, Alexis; Henley, Alan; Baker, Ross; McAndrew, Craig; Matijssen, Berry; Burke, Rosemary; Hoelder, Swen; Eccles, Suzanne A; Raynaud, Florence I; Linardopoulos, Spiros; van Montfort, Rob L M; Blagg, Julian
信号转导
发表日期：2013
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Functional viability profiles of breast cancer.

乳腺癌的功能性生存特征

期刊:Cancer Discovery
影响因子:33.3
doi:10.1158/2159-8290.CD-11-0107
Brough Rachel, Frankum Jessica R, Sims David, Mackay Alan, Mendes-Pereira Ana M, Bajrami Ilirjana, Costa-Cabral Sara, Rafiq Rumana, Ahmad Amar S, Cerone Maria Antonietta, Natrajan Rachael, Sharpe Rachel, Shiu Kai-Keen, Wetterskog Daniel, Dedes Konstantine J, Lambros Maryou B, Rawjee Teeara, Linardopoulos Spiros, Reis-Filho Jorge S, Turner Nicholas C, Lord Christopher J, Ashworth Alan
肿瘤
乳腺癌
肿瘤免疫
发表日期：2011
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The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo

极光激酶抑制剂CCT137690可下调MYCN表达，并在体内增强MYCN扩增型神经母细胞瘤的敏感性。

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-11-0333
Faisal, Amir; Vaughan, Lynsey; Bavetsias, Vassilios; Sun, Chongbo; Atrash, Butrus; Avery, Sian; Jamin, Yann; Robinson, Simon P; Workman, Paul; Blagg, Julian; Raynaud, Florence I; Eccles, Suzanne A; Chesler, Louis; Linardopoulos, Spiros
信号转导
细胞生物学
MYC
发表日期：2011
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Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

表达Aurora-A的肿瘤细胞缺乏同源定向DNA双链断裂修复能力，并且对PARP抑制剂敏感。

期刊:EMBO Molecular Medicine
影响因子:8.3
doi:10.1002/emmm.201000068
Sourisseau, Tony; Maniotis, Despina; McCarthy, Afshan; Tang, Chan; Lord, Christopher J; Ashworth, Alan; Linardopoulos, Spiros
肿瘤
肿瘤免疫
PARP
细胞生物学
肿瘤细胞
发表日期：2010
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