日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In Vivo Auto-tuning of Antibody-Drug Conjugate Delivery to Maximize Efficacy Using High-Avidity, Low-Affinity Antibodies

利用高亲和力、低亲和力抗体,在体内自动调节抗体-药物偶联物递送以最大限度地提高疗效

Kopp, Anna; Dong, Shujun; Kwon, Hyeyoung; Wang, Tiexin; Desai, Alec A; Philippart, Andrew; Koo, Dong Jun; Linderman, Jennifer J; Tessier, Peter M; Thurber, Greg M

Inference of weak-form partial differential equations describing migration and proliferation mechanisms in wound healing experiments on cancer cells

推断描述癌细胞伤口愈合实验中迁移和增殖机制的弱形式偏微分方程

Srivastava, Siddhartha; Kinnunen, Patrick C; Wang, Zhenlin; Ho, Kenneth K Y; Humphries, Brock A; Chen, Siyi; Linderman, Jennifer J; Luker, Gary D; Luker, Kathryn E; Garikipati, Krishna

Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden

结核病抗生素治疗方案的排名对空间尺度、检测限和宿主初始细菌载量都很敏感。

Michael, Christian T; Budak, Maral; Maiello, Pauline; Kracinovsky, Kara; Rodgers, Mark; Tomko, Jaime; Lin, Philana Ling; Flynn, JoAnne; Linderman, Jennifer J; Kirschner, Denise

Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays

利用阈值抑制曲面和剂量滴定试验,通过计算和实验方法表征异质性单细胞剂量反应

Kinnunen, Patrick C; Humphries, Brock A; Luker, Gary D; Luker, Kathryn E; Linderman, Jennifer J

Integrating inverse reinforcement learning into data-driven mechanistic computational models: a novel paradigm to decode cancer cell heterogeneity

将逆强化学习整合到数据驱动的机制计算模型中:一种解码癌细胞异质性的新范式

Kinnunen, Patrick C; Ho, Kenneth K Y; Srivastava, Siddhartha; Huang, Chengyang; Shen, Wanggang; Garikipati, Krishna; Luker, Gary D; Banovic, Nikola; Huan, Xun; Linderman, Jennifer J; Luker, Kathryn E

Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens

优化结核病治疗效果:比较标准方案与含莫西沙星方案

Budak, Maral; Cicchese, Joseph M; Maiello, Pauline; Borish, H Jacob; White, Alexander G; Chishti, Harris B; Tomko, Jaime; Frye, L James; Fillmore, Daniel; Kracinovsky, Kara; Sakal, Jennifer; Scanga, Charles A; Lin, Philana Ling; Dartois, Véronique; Linderman, Jennifer J; Flynn, JoAnne L; Kirschner, Denise E

A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons

多尺度干预建模框架:虚拟队列、虚拟临床试验和模型间比较

Michael, Christian T; Almohri, Sayed Ahmad; Linderman, Jennifer J; Kirschner, Denise E

Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2-Positive Tumors

利用旁观者杀伤和抗体联合给药模拟异质性人表皮生长因子受体2阳性肿瘤中耐药细胞的选择

Menezes, Bruna; Linderman, Jennifer J; Thurber, Greg M

Concomitant immunity to M. tuberculosis infection

对结核分枝杆菌感染的伴随免疫力

Joslyn, Louis R; Flynn, JoAnne L; Kirschner, Denise E; Linderman, Jennifer J

Corrigendum: Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas

更正:非特异性 T 细胞的空间组织和募集可能限制结核分枝杆菌肉芽肿内的 T 细胞-巨噬细胞相互作用

Millar, Jess A; Butler, J Russell; Evans, Stephanie; Grant, Nicole L; Mattila, Joshua T; Linderman, Jennifer J; Flynn, JoAnne L; Kirschner, Denise E