文献库，生知库 | 链接生命科学的每一步

日期影响因子

Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity

NF-κB在模拟IRF3-IFN免疫先天缺陷的小鼠疱疹性脑炎病理中的作用

期刊:Journal of Experimental Medicine

影响因子:12.6

doi:10.1084/jem.20250064.

Manja Idorn,Xiangning Ding,Stefanie Fruhwürth,Søren Holste,Line S Reinert,Christian S Skoven,Katarina Türner-Stenström,Alexander Schmitz,Mikkel H Vendelbo,Benedicte P Ulhøi,Dzeneta Vizlin-Hodzic,Mona Wefelmeyer,Ryo Narita,Lona J Kroese,Ivo J Huijbers,Michelle Møhlenberg,Anne Kruse Hollensen,Xin Lai,Marie B Iversen,Brian Hansen,Trine H Mogensen,Søren R Paludan

免疫/内分泌

发表日期：2026

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Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection

时间分辨单细胞RNA测序揭示单纯疱疹病毒中枢神经系统感染期间的保护性和病理性反应

期刊:Journal of Neuroinflammation

影响因子:9.3

doi:10.1186/s12974-025-03471-x

Xiangning Ding ，Xin Lai ，Ida H Klaestrup ，Sara R N Jensen ，Morten M Nielsen ，Kasper Thorsen ，Marina Romero-Ramos ，Yonglun Luo ，Lin Lin ，Line S Reinert # ，Søren R Paludan #

细胞生物学

发表日期：2025

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TMEFF1 is a neuron-specific restriction factor for herpes simplex virus

TMEFF1 是单纯疱疹病毒的神经元特异性限制因子

影响因子:50.5

doi:10.1038/s41586-024-07670-z

Yao Dai #, Manja Idorn #, Manutea C Serrero, Xiaoyong Pan, Emil A Thomsen, Ryo Narita, Muyesier Maimaitili, Xiaoqing Qian, Marie B Iversen, Line S Reinert, Rasmus K Flygaard, Muwan Chen, Xiangning Ding, Bao-Cun Zhang, Madalina E Carter-Timofte, Qing Lu, Zhuofan Jiang, Yiye Zhong, Shuhui Zhang, Linta

发表日期：2024

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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

HIF转录网络在神经元中发挥固有的抗病毒活性，并限制脑部炎症。

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2024.113792

Ensieh Farahani,Line S Reinert,Ryo Narita,Manutea C Serrero,Morten Kelder Skouboe,Demi van der Horst,Sonia Assil,Baocun Zhang,Marie B Iversen,Eugenio Gutierrez,Hossein Hazrati,Mogens Johannsen,David Olagnier,Reiner Kunze,Mark Denham,Trine H Mogensen,Michael Lappe,Søren R Paludan

Immunology/Inflammation

发表日期：2024

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Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice

基于粘膜 IFNλ1 mRNA 的免疫调节可有效降低 SARS-CoV-2 诱导的小鼠死亡率

期刊:EMBO Reports

影响因子:6.5

doi:10.1038/s44319-024-00216-4

Anna Macht #, Yiqi Huang #, Line S Reinert #, Vincent Grass, Kristin Lohmer, Elke Tatjana Aristizabal Prada, Eveline Babel, Alexandra Semmler, Wen Zhang, Andrea Wegner, Eva Lichtenegger-Hartl, Sonja Haas, Günther Hasenpusch, Steffen Meyer, Søren R Paludan #, Andreas Pichlmair #, Carsten Rudolph #, T

发表日期：2024

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The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice

热休克蛋白 90 抑制剂 RGRN-305 可在体外减轻 SARS-CoV-2 刺突蛋白诱发的炎症，但在小鼠中作为 COVID-19 治疗无效

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0310915

Hakim Ben Abdallah, Giorgia Marino, Manja Idorn, Line S Reinert, Anne Bregnhøj, Søren Riis Paludan, Claus Johansen

Immunology/Inflammation

发表日期：2024

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TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain

HSV1 在小胶质细胞中下调 TREM2，并参与大脑的抗病毒防御

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.adf5808

Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R Paludan

细胞生物学

发表日期：2023

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ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2

内质网应激诱导单纯疱疹病毒2型裂解性感染的神经元发生caspase-2-tBID-GSDME依赖性细胞死亡。

期刊:EMBO Journal

影响因子:9.4

doi:10.15252/embj.2022113118

Fanghui Ren ,Ryo Narita ,Ahmad S Rashidi ,Stefanie Fruhwürth ,Zongliang Gao ,Rasmus O Bak ,Martin K Thomsen ,Georges Mgm Verjans ,Line S Reinert ,Søren R Paludan

内质网应激

细胞生物学

发表日期：2023

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STING is redundant for host defense and pathology of COVID-19-like disease in mice

STING 对小鼠宿主防御和 COVID-19 样疾病的病理学而言是多余的

期刊:Life Science Alliance

影响因子:3.3

doi:10.26508/lsa.202301997

Giorgia Marino, Baocun Zhang, Alexander Schmitz, Hanna Vf Schwensen, Line S Reinert, Søren R Paludan

发表日期：2023

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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

STING 协调多不饱和脂肪酸代谢和炎症反应之间的相互作用

期刊:Cell Metabolism

影响因子:27.7

doi:10.1016/j.cmet.2021.12.007

Isabelle K Vila ，Hanane Chamma ，Alizée Steer ，Mathilde Saccas ，Clara Taffoni ，Evgenia Turtoi ，Line S Reinert ，Saqib Hussain ，Johanna Marines ，Lei Jin ，Xavier Bonnefont ，Mathieu Hubert ，Olivier Schwartz ，Soren R Paludan ，Gaetan Van Simaeys ，Gilles Doumont ，Bijan Sobhian ，Dimitrios Vlachakis ，Andrei Turtoi ，Nadine Laguette

发表日期：2022

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