日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale RNA-Seq mining reveals ciclopirox olamine induces TDP-43 cryptic exons.

大规模 RNA-Seq 挖掘揭示环吡咯醇胺诱导 TDP-43 隐蔽外显子

Sinha Irika R, Sandal Parker S, Spence Holly, Burns Grace D, Mallika Aswathy Peethambaran, Abbasinejad Fatemeh, Irwin Katherine E, Cruz Anna Lourdes F, Wang Vania, Marx Shaelyn R, Rodríguez Josué Llamas, Langmead Ben, Gregory Jenna M, Wong Philip C, Ling Jonathan P

Distinct and convergent effects of SF3B1 mutations in human breast cancer

SF3B1突变在人类乳腺癌中的独特和趋同效应

Bergman, Riley E; Keeton, Christin I; Sinha, Irika R; Ling, Jonathan P; Wang, Yu; Ha, Lauren; Mehta, Eshani P; Reed, Sarah C; Fox, Ethan K; O'Grady, Tina M; Yu, Yingying; Fragkogianni, Stamatina; Chao, Calvin; Davidson, Brad A; Miranda, Adam X; Croessmann, Sarah; Zhao, Shilin; Liu, Qi; Shyr, Yu; Dalton, W Brian; Hurley, Paula J; Park, Ben H

Barriers and facilitators to accessing healthcare for early diagnosis of prostate cancer for black men-a qualitative exploration in North-East England and Scotland

黑人男性获得前列腺癌早期诊断医疗保健服务的障碍和促进因素——英格兰东北部和苏格兰的一项定性探索

Christie-de Jong, Floor; Oyeniyi, Olugbenga Samuel; Nnyanzi, Lawrence Achilles; Ling, Jonathan; Murphy, Marie K; Eberhardt, Judith; Jarrar, Rawand; Kabuye, John; Kalemba, Martin; Robb, Kathryn A

Barriers and Facilitators of NHS Health Checks in Socioeconomically Deprived Communities in the North East of England: A Qualitative Study With Peer Researchers

英格兰东北部社会经济欠发达社区参与国民医疗服务体系(NHS)健康检查的障碍和促进因素:一项由同伴研究人员参与的定性研究

Eberhardt, Judith; Kane, Laura; Portman, Robert; Ling, Jonathan; Goddard, Tracy; Johnston, Mark; Robinson, Claire; Reay, Abigail; Divers, Andrew; Newbury-Birch, Dorothy

Factors contributing to under-5 child mortality in Nigeria: A narrative review

尼日利亚五岁以下儿童死亡率的影响因素:叙述性综述

Olawade, David B; Wada, Ojima Z; Aderinto, Nicholas; Odetayo, Aderonke; Adebisi, Yusuff Adebayo; Esan, Deborah Tolulope; Ling, Jonathan

5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins

5-乙炔基尿苷扰乱核内RNA代谢,促进TDP-43和其他RNA结合蛋白在核内积累。

Hayes, Lindsey R; Zaepfel, Benjamin; Duan, Lauren; Starner, Anne C; Bartels, Mason D; Rothacher, Rebekah L; Martin, Sophie; French, Rachel; Zhang, Zhe; Sinha, Irika R; Ling, Jonathan P; Sun, Shuying; Ayala, Yuna M; Coller, Jeff; Van Nostrand, Eric L; Florea, Liliana; Kalab, Petr

Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Demenia-like deficits

通过腺相关病毒(AAV)实现广泛的脑生物分布,从而恢复TDP-43功能,减轻额颞叶痴呆样症状。

Cao, Tianyu; Thapa, Rashmi; Liu, Rongsong; Mallika, Aswathy Peethambaran; Baghel, Meghraj Singh; Wei, Yijun; Sinha, Irika R; Burns, Grace D; Wen, Xinrui; Pang, Bo; Ling, Jonathan P; Lin, Da-Ting; Li, Yun; Wong, Philip C

Symptomatic treatment by a BBB-permeable AAV engineered to restore TDP-43 function slows motor neuron disease and prevents paralysis

利用经基因工程改造、可穿透血脑屏障的腺相关病毒(AAV)进行对症治疗,能够恢复TDP-43功能,从而延缓运动神经元疾病的进展并预防瘫痪。

Peethambaran Mallika, Aswathy; Yu, Jessica G; Sitzman, Opal; Baghel, Meghraj Singh; Renganathan, Shruti; Sinha, Irika R; Melnikova, Tatiana; Ling, Jonathan P; Wong, Philip C

Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons

抑制TDP-43缺陷神经元中的无义介导衰变可揭示新的隐蔽外显子

Sinha, Irika R; Ye, Yingzhi; Li, Yini; Sandal, Parker S; Wong, Philip C; Sun, Shuying; Ling, Jonathan P

Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis.

脑铁作为病理性 TDP-43 的替代生物标志物,可识别衰老、阿尔茨海默病和肌萎缩侧索硬化症中脑区特异性特征。

Waldron Fergal M, Spence Holly, Taso Orjona Stella, Read Fiona L, Sinha Irika R, Irwin Katherine E, Wong Philip C, Ling Jonathan P, Gregory Jenna M