Folate promotes colorectal cancer progression by impairing CD8(+) T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation
叶酸通过SLC19A1/p-AKT/NOTCH1轴和CCL5下调抑制CD8(+) T细胞的功能和募集，从而促进结直肠癌的进展。
期刊:Journal of Translational Medicine
影响因子:7.5
doi:10.1186/s12967-026-07993-7
Qing, Shunjie; Ling, Yunyan; Lai, Yingjie; Hu, Yating; Zhong, Yi; Liu, Yuechen; Liu, Xiang; Fang, Yuan; Qian, Junying; Deng, Haijun; Peng, Yifeng; Wu, Dehua; Shen, Zhiyong
肿瘤
肠癌
T细胞
OTC
CCL5
NOTCH
肿瘤免疫
CD8
T细胞
细胞生物学
AKT
免疫/内分泌
