日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.

通过深度突变扫描绘制MET受体酪氨酸激酶的激酶结构域抗性机制图谱

Estevam Gabriella O, Linossi Edmond, Rao Jingyou, Macdonald Christian B, Ravikumar Ashraya, Chrispens Karson M, Capra John A, Coyote-Maestas Willow, Pimentel Harold, Collisson Eric A, Jura Natalia, Fraser James S

Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domain

MET受体酪氨酸激酶通过其胞内近膜结构域进行自身调节

Linossi, Edmond M; Espinoza, Carla A; Estevam, Gabriella O; Fraser, James S; Jura, Natalia

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

通过对 MET 受体酪氨酸激酶结构域进行深度突变扫描,揭示了近膜结构域和激酶 N 叶中保守的调控基序

Gabriella O Estevam, Edmond M Linossi, Christian B Macdonald, Carla A Espinoza, Jennifer M Michaud, Willow Coyote-Maestas, Eric A Collisson, Natalia Jura, James S Fraser

Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

通过对MET受体酪氨酸激酶结构域进行深度突变扫描,揭示了近膜结构域和激酶N叶中的保守调控基序。

Estevam, Gabriella O; Linossi, Edmond M; Macdonald, Christian B; Espinoza, Carla A; Michaud, Jennifer M; Coyote-Maestas, Willow; Collisson, Eric A; Jura, Natalia; Fraser, James S

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

通过深度突变扫描绘制 MET 受体酪氨酸激酶的激酶结构域抗性机制

Gabriella O Estevam, Edmond M Linossi, Jingyou Rao, Christian B Macdonald, Ashraya Ravikumar, Karson M Chrispens, John A Capra, Willow Coyote-Maestas, Harold Pimentel, Eric A Collisson, Natalia Jura, James S Fraser

First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors

MP0250(一种靶向VEGF和HGF的首创DARPin候选药物)在晚期实体瘤患者中的首次人体I期研究

Baird, Richard D; Linossi, Constanza; Middleton, Mark; Lord, Simon; Harris, Adrian; Rodón, Jordi; Zitt, Christof; Fiedler, Ulrike; Dawson, Keith M; Leupin, Nicolas; Stumpp, Michael T; Harstrick, Andreas; Azaro, Analía; Fischer, Stefanie; Omlin, Aurelius

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

在 SOCS2-SH2 结构域上发现一个外部位点,可增强 SH2 与磷酸化配体的结合

Edmond M Linossi #, Kunlun Li #, Gianluca Veggiani #, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J Calleja, Narelle Keating, Rebecca Feltham, Andrew J Brooks, Shawn S Li, Sachdev S Sidhu, Jeffrey J Babon, Nadia J Kershaw, Sandra E Nicholson

State of the structure address on MET receptor activation by HGF

HGF激活MET受体的结构地址状态

Linossi, Edmond M; Estevam, Gabriella O; Oshima, Masaya; Fraser, James S; Collisson, Eric A; Jura, Natalia

A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics

对激酶组药典的调查揭示了开发新型驱虫药的多种支架和靶点

Jessica Knox, Nicolas Joly, Edmond M Linossi, José A Carmona-Negrón, Natalia Jura, Lionel Pintard, William Zuercher, Peter J Roy

Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data

基于DNA甲基化谱和转录组与基因组数据整合的巴雷特食管和食管腺癌亚型鉴定

Jammula, SriGanesh; Katz-Summercorn, Annalise C; Li, Xiaodun; Linossi, Constanza; Smyth, Elizabeth; Killcoyne, Sarah; Biasci, Daniele; Subash, Vinod V; Abbas, Sujath; Blasko, Adrienn; Devonshire, Ginny; Grantham, Amber; Wronowski, Filip; O'Donovan, Maria; Grehan, Nicola; Eldridge, Matthew D; Tavaré, Simon; Fitzgerald, Rebecca C