日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Trastuzumab deruxtecan efficacy, FcRn-facilitated penetration of the blood-tumor barrier, and distribution to tumor cells in HER2+ brain metastasis model systems

曲妥珠单抗德鲁替康的疗效、FcRn介导的血肿瘤屏障穿透以及在HER2阳性脑转移模型系统中向肿瘤细胞的分布

Khan, Imran; Kumar, Dinesh; Zhang, Wei; Difilippantonio, Simone; Robinson, Christina; Wei, Debbie; Lipkowitz, Stanley; Lake, Ross; Fleming, Ronald; Steeg, Patricia S

TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells

TRAIL通过NF-κB2通路诱导细胞因子产生,促进中性粒细胞趋化和中性粒细胞介导的免疫抑制,从而增强三阴性乳腺癌细胞的免疫活性。

Kundu, Manjari; Greer, Yoshimi E; Lobanov, Alexei; Ridnour, Lisa; Donahue, Renee N; Ng, Yeap; Ratnayake, Shashi; White, Karley; Voeller, Donna; Weltz, Sarah; Chen, Qingrong; Lockett, Stephen J; Cam, Maggie; Meerzaman, Daoud; Wink, David A; Weigert, Roberto; Lipkowitz, Stanley

Proteogenomic characterization of invasive breast tumors in young women

年轻女性浸润性乳腺肿瘤的蛋白质基因组学特征分析

Raj-Kumar, Praveen-Kumar; Liu, Jianfang; Soltis, Anthony R; Bateman, Nicholas W; Chen, Qingrong; Sturtz, Lori A; Deyarmin, Brenda; Pierobon, Mariaelena; Abulez, Tamara A; Praveen-Kumar, Anupama; Zhang, Xijun; Nguyen, Trinh; Yan, Chunhua; Hu, Ying; Guion, Kate; Hooke, Jeffrey A; Kovatich, Albert J; Fantacone-Campbell, Leigh; Mostoller, Brad; Kvecher, Leonid; Somiari, Stella; Steeg, Patricia S; Rajagopal, Padma Sheila; Darcy, Kathleen M; Lee, Jerry S H; Dalgard, Clifton L; Conrads, Thomas P; Petricoin, Emanuel F; Meerzaman, Daoud; Wilkerson, Matthew D; Lin, Xiaoying; Shriver, Craig D; Lipkowitz, Stanley; Hu, Hai

US cancer deaths prevented due to survival improvements stratified by extent of disease, 2010-2019

2010-2019年美国因生存率提高而避免的癌症死亡人数(按疾病程度分层)

Shiels, Meredith S; Freedman, Neal D; Haque, Anika T; Berrington de González, Amy; Lipkowitz, Stanley; Lowy, Douglas R; Pfeiffer, Ruth M

Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER- breast cancer

肿瘤NOS2/COX2水平升高会促进与ER阴性乳腺癌患者预后不良相关的免疫抑制表型。

Ridnour, Lisa A; Cheng, Robert Ys; Heinz, William F; Pore, Milind; Gonzalez, Ana L; Femino, Elise L; Moffat, Rebecca L; Wink, Adelaide L; Imtiaz, Fatima; Coutinho, Leandro L; Butcher, Donna; Edmondson, Elijah F; Rangel, M Cristina; Wong, Stephen Tc; Lipkowitz, Stanley; Glynn, Sharon A; Vitek, Michael P; McVicar, Daniel W; Li, Xiaoxian; Anderson, Stephen K; Paolocci, Nazareno; Hewitt, Stephen M; Ambs, Stefan; Billiar, Timothy R; Chang, Jenny C; Lockett, Stephen J; Wink, David A

Revisiting surrogacy of pathological complete response for long-term survival in triple-negative breast cancer

重新审视病理完全缓解作为三阴性乳腺癌长期生存的替代指标

Yoshino, Toru; Zhang, Zao; Sato, Ryota; Lipkowitz, Stanley; Fujii, Takeo

A CSF-1R inhibitor both prevents and treats triple-negative breast cancer brain metastases in hematogenous preclinical models.

CSF-1R 抑制剂在血液传播的临床前模型中既能预防又能治疗三阴性乳腺癌脑转移

Zhang Wei, Rahman Samiur, Wu Alex M L, Isanogle Kristine, Robinson Christina, Kumar Dinesh, Khan Imran, Wei Debbie, Zimmer Alexandra S, Fujii Takeo, Difilippantonio Simone, Lipkowitz Stanley, Steeg Patricia

A Phase II Pilot Study of Anti-PD-L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple-Negative Breast Cancer With or Without Germline BRCA Mutation.

一项针对伴或不伴有生殖系 BRCA 突变的转移性三阴性乳腺癌患者的 II 期试点研究,评估抗 PD-L1 药物 Durvalumab 和 PARP 抑制剂 Olaparib 的疗效。

Fujii Takeo, Cimino-Mathews Ashley, Lipkowitz Stanley, Lee Min-Jung, Nair Jayakumar, Solarz Britanny Brooke, Zimmer Alexandra, Redd Bernadette, Levy Elliot B, Rastogi Shraddha, Sato Nahoko, McCoy Ann, Steinberg Seth M, Lee Jung-Min

Small Molecule Activators of the Mitochondrial Protease ClpP Induce Senescence in Triple-Negative Breast Cancer Cells and Sensitize Cells to the Bcl-2 Inhibitor Venetoclax

线粒体蛋白酶ClpP的小分子激活剂可诱导三阴性乳腺癌细胞衰老,并使细胞对Bcl-2抑制剂维奈托克敏感。

Daglish, Sabrina C D; Canterbury, Owen G; Graves, Paul R; Carter, Sarah A; Beese, Sydney M; Hynek, Maggie A; Mouery, Brandon L; Mistreanu, Andrei J; Bhatt, Aadra P; Tellez, Nestor; Butler, Mitchell T; Aponte-Collazo, Lucas J; Fennell, Emily M J; Herring, Laura E; Lyons, Scott; Mills, C Allie; Ashamalla, Hani; Iwanowicz, Edwin J; Morris, John P 4th; Bear, James E; Greer, Yoshimi Endo; Lipkowitz, Stanley; Graves, Lee M

Phase II proof-of-concept study of durvalumab and cediranib with and without olaparib in recurrent ovarian cancer

一项针对复发性卵巢癌的 II 期概念验证研究,评估度伐利尤单抗和西地尼布联合或不联合奥拉帕尼的疗效

Lee, Jung-Min; Tabata, Junya; Huang, Tzu-Ting; Giudice, Elena; Ibanez, Kristen; Nair, Jayakumar; Warner, Aanika; Solarz, Britanny; Bolanos, Valentina; Redd, Bernadette; Sato, Nahoko; Rastogi, Shraddha; Lee, Sunmin; Shrestha, Roshan; Mitrophanov, Alexander; Lipkowitz, Stanley; Conlon, Kevin; Huang, Chien Chu