日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of New KCNT1-Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling

利用计算机模拟、细胞和果蝇模型鉴定新的KCNT1癫痫药物

Ricos, Michael G; Cole, Bethan A; Hussain, Rashid; Rychkov, Grigori Y; Shaukat, Zeeshan; Pilati, Nadia; Muench, Stephen P; Simmons, Katie J; Dibbens, Leanne M; Lippiat, Jonathan D

Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy

表达突变人类 KCNT1 转基因的果蝇成为 KCNT1 癫痫整体动物模型中靶向药物筛选的有效工具

Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat, Anowarul Islam, Emily A Caseley, Jonathan D Lippiat, Grigori Y Rychkov, Michael G Ricos, Leanne M Dibbens

A molecular switch in RCK2 triggers sodium-dependent activation of K(Na)1.1 (KCNT1) potassium channels

RCK2 中的分子开关触发 K(Na)1.1 (KCNT1) 钾通道的钠依赖性激活。

Cole, Bethan A; Kalli, Antreas C; Pilati, Nadia; Muench, Stephen P; Lippiat, Jonathan D

Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling

硫化氢抑制电压门控钾通道 Kv1.5 可减弱通过 S-亚硝化介导的信号传导引起的重塑

Moza M Al-Owais, Nishani T Hettiarachchi, Mark L Dallas, Jason L Scragg, Jonathan D Lippiat, Arun V Holden, Derek S Steele, Chris Peers

Author Correction: Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

作者更正:环烷烃修饰的两亲性聚合物可直接提取膜蛋白用于冷冻电镜分析。

Higgins, Anna J; Flynn, Alex J; Marconnet, Anaïs; Musgrove, Laura J; Postis, Vincent L G; Lippiat, Jonathan D; Chung, Chun-Wa; Ceska, Tom; Zoonens, Manuela; Sobott, Frank; Muench, Stephen P

TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection

TMEM16A/ANO1钙激活氯通道作为治疗人类呼吸道合胞病毒感染的新靶点

Hayley Pearson, Eleanor J A A Todd, Mareike Ahrends, Samantha E Hover, Adrian Whitehouse, Martin Stacey, Jonathan D Lippiat, Ludwig Wilkens, Hans-Gerd Fieguth, Olga Danov, Christina Hesse, John N Barr, Jamel Mankouri

Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism

Kv1.3 电压门控钾通道通过非传导机制将细胞呼吸与增殖联系起来

Faye L Styles, Moza M Al-Owais, Jason L Scragg, Eulashini Chuntharpursat-Bon, Nishani T Hettiarachchi, Jonathan D Lippiat, Aisling Minard, Robin S Bon, Karen Porter, Piruthivi Sukumar, Chris Peers, Lee D Roberts

Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

环烷烃修饰的两亲性聚合物可直接提取膜蛋白用于冷冻电镜分析。

Higgins, Anna J; Flynn, Alex J; Marconnet, Anaïs; Musgrove, Laura J; Postis, Vincent L G; Lippiat, Jonathan D; Chung, Chun-Wa; Ceska, Tom; Zoonens, Manuela; Sobott, Frank; Muench, Stephen P

Small molecules restore the function of mutant CLC5 associated with Dent disease

小分子可恢复与Dent病相关的突变CLC5的功能。

Liu, Jingshu; Sadeh, Tal T; Lippiat, Jonathan D; Thakker, Rajesh V; Black, Graeme C; Manson, Forbes

Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives

离子通道作为病毒感染的治疗靶点:进一步的发现和未来展望

Charlton, Frank W; Pearson, Hayley M; Hover, Samantha; Lippiat, Jon D; Fontana, Juan; Barr, John N; Mankouri, Jamel